The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
The Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Although cell signaling pathways triggered by the transcription factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in fully malignant cells Nrf2 act...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231712000110 |
| _version_ | 1818499117989494784 |
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| author | Emilia Kansanen Suvi M. Kuosmanen Hanna Leinonen Anna-Liisa Levonen |
| author_facet | Emilia Kansanen Suvi M. Kuosmanen Hanna Leinonen Anna-Liisa Levonen |
| author_sort | Emilia Kansanen |
| collection | DOAJ |
| description | The Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Although cell signaling pathways triggered by the transcription factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in fully malignant cells Nrf2 activity provides growth advantage by increasing cancer chemoresistance and enhancing tumor cell growth. In this graphical review, we provide an overview of the Keap1-Nrf2 pathway and its dysregulation in cancer cells. We also briefly summarize the consequences of constitutive Nrf2 activation in cancer cells and how this can be exploited in cancer gene therapy. |
| first_indexed | 2024-12-10T20:24:57Z |
| format | Article |
| id | doaj.art-70d22406e453436b8fe9ea4a4adc6c3a |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-10T20:24:57Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-70d22406e453436b8fe9ea4a4adc6c3a2022-12-22T01:34:54ZengElsevierRedox Biology2213-23172013-01-0111454910.1016/j.redox.2012.10.001The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancerEmilia KansanenSuvi M. KuosmanenHanna LeinonenAnna-Liisa LevonenThe Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Although cell signaling pathways triggered by the transcription factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in fully malignant cells Nrf2 activity provides growth advantage by increasing cancer chemoresistance and enhancing tumor cell growth. In this graphical review, we provide an overview of the Keap1-Nrf2 pathway and its dysregulation in cancer cells. We also briefly summarize the consequences of constitutive Nrf2 activation in cancer cells and how this can be exploited in cancer gene therapy.http://www.sciencedirect.com/science/article/pii/S2213231712000110Nrf2Keap1CancerAntioxidant response elementGene therapy |
| spellingShingle | Emilia Kansanen Suvi M. Kuosmanen Hanna Leinonen Anna-Liisa Levonen The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer Redox Biology Nrf2 Keap1 Cancer Antioxidant response element Gene therapy |
| title | The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer |
| title_full | The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer |
| title_fullStr | The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer |
| title_full_unstemmed | The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer |
| title_short | The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer |
| title_sort | keap1 nrf2 pathway mechanisms of activation and dysregulation in cancer |
| topic | Nrf2 Keap1 Cancer Antioxidant response element Gene therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213231712000110 |
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