Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and ApoptosisSummary

Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and ApoptosisSummary

Background & Aims: Bcl-xL, an anti-apoptotic Bcl-2 family protein, is overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, Bcl-xL expression in pancreatic intraepithelial neoplasias (PanINs) and its significance in PDAC carcinogenesis remain unclear. The aim of this st...

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Bibliographic Details
Main Authors: Kenji Ikezawa, Hayato Hikita, Minoru Shigekawa, Kiyoshi Iwahashi, Hidetoshi Eguchi, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17300309

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