Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial
Schizophrenia is a severe psychiatric condition that affects approximately 1% of the global population. Over the last decade, the efficacy of berberine as a complementary therapy in psychiatric diseases without significant side effects has been demonstrated. Therefore, this study assessed the effec...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-09-01
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| Series: | Traditional and Integrative Medicine |
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| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/597 |
| _version_ | 1798029105927553024 |
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| author | Ebrahim Moghimi Sarani Fatemeh Ghorbannezhad Mohammad Hassan Meshkibaf Marjan Shakibaee Seyed Hamdollah Mosavat |
| author_facet | Ebrahim Moghimi Sarani Fatemeh Ghorbannezhad Mohammad Hassan Meshkibaf Marjan Shakibaee Seyed Hamdollah Mosavat |
| author_sort | Ebrahim Moghimi Sarani |
| collection | DOAJ |
| description |
Schizophrenia is a severe psychiatric condition that affects approximately 1% of the global population. Over the last decade, the efficacy of berberine as a complementary therapy in psychiatric diseases without significant side effects has been demonstrated. Therefore, this study assessed the effect of alkaloid berberine on the positive and negative symptoms in patients with schizophrenia. From December 2020 to March 2021, a total of 86 patients with schizophrenia who were referred to Shiraz Ebne Sina Hospital in South of Iran were divided into two groups; 42 patients with schizophrenia in the placebo group received risperidone at a dosage of 4-6 mg per day, and 44 patients in the treatment group, in addition to risperidone, received berberine at a dosage of 500 mg per day. This treatment regimen was followed for 30 days. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients’ symptoms. According to data analysis, The PANSS score in both groups showed a statistically significant decrease after 30 days (p < 0.05); however, this decreasing trend was not statistically significant between the groups (p > 0.05). The current study showed that complementary use of alkaloid berberine capsule with a dose of 500 mg per day did not show better outcomes compared with the placebo in patients with schizophrenia.
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| first_indexed | 2024-04-11T19:19:56Z |
| format | Article |
| id | doaj.art-70d9f11da8384c09b386fa5879af87cb |
| institution | Directory Open Access Journal |
| issn | 2476-5104 2476-5112 |
| language | English |
| last_indexed | 2024-04-11T19:19:56Z |
| publishDate | 2022-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj.art-70d9f11da8384c09b386fa5879af87cb2022-12-22T04:07:20ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122022-09-017310.18502/tim.v7i3.10769Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical TrialEbrahim Moghimi Sarani0Fatemeh Ghorbannezhad1Mohammad Hassan Meshkibaf2Marjan Shakibaee3Seyed Hamdollah Mosavat4Department of Psychiatric, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Psychiatric, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, IranDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, IranResearch Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Schizophrenia is a severe psychiatric condition that affects approximately 1% of the global population. Over the last decade, the efficacy of berberine as a complementary therapy in psychiatric diseases without significant side effects has been demonstrated. Therefore, this study assessed the effect of alkaloid berberine on the positive and negative symptoms in patients with schizophrenia. From December 2020 to March 2021, a total of 86 patients with schizophrenia who were referred to Shiraz Ebne Sina Hospital in South of Iran were divided into two groups; 42 patients with schizophrenia in the placebo group received risperidone at a dosage of 4-6 mg per day, and 44 patients in the treatment group, in addition to risperidone, received berberine at a dosage of 500 mg per day. This treatment regimen was followed for 30 days. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients’ symptoms. According to data analysis, The PANSS score in both groups showed a statistically significant decrease after 30 days (p < 0.05); however, this decreasing trend was not statistically significant between the groups (p > 0.05). The current study showed that complementary use of alkaloid berberine capsule with a dose of 500 mg per day did not show better outcomes compared with the placebo in patients with schizophrenia. https://jtim.tums.ac.ir/index.php/jtim/article/view/597Alkaloid berberinePositive and negative syndrome scale (PANSS)Schizophrenia |
| spellingShingle | Ebrahim Moghimi Sarani Fatemeh Ghorbannezhad Mohammad Hassan Meshkibaf Marjan Shakibaee Seyed Hamdollah Mosavat Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial Traditional and Integrative Medicine Alkaloid berberine Positive and negative syndrome scale (PANSS) Schizophrenia |
| title | Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial |
| title_full | Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial |
| title_fullStr | Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial |
| title_short | Evaluation of the Effect of Alkaloid Berberine on the Positive and Negative Symptoms of the Patients with Schizophrenia: A Double-Blind Randomized Placebo-Controlled Clinical Trial |
| title_sort | evaluation of the effect of alkaloid berberine on the positive and negative symptoms of the patients with schizophrenia a double blind randomized placebo controlled clinical trial |
| topic | Alkaloid berberine Positive and negative syndrome scale (PANSS) Schizophrenia |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/597 |
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