Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

The blood–brain barrier (BBB) poses major challenges to drug delivery to the CNS. SFTI-1 and kalata B1 are cyclic cell-penetrating peptides (cCPPs) with high potential to be used as scaffolds for drug delivery. We here studied their transport across the BBB and distribution within the brain to gauge...

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Bibliographic Details
Main Authors: Erik Melander, Camilla Eriksson, Sara Wellens, Kimia Hosseini, Robert Fredriksson, Fabien Gosselet, Maxime Culot, Ulf Göransson, Margareta Hammarlund-Udenaes, Irena Loryan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
cyclic peptide
cell-penetrating peptide
kalata B1
SFTI-1
blood–brain barrier
intracellular distribution
Online Access:https://www.mdpi.com/1999-4923/15/5/1507

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