B-Cell Memory Responses to Variant Viral Antigens
A central feature of vertebrate immune systems is the ability to form antigen-specific immune memory in response to microbial challenge and so provide protection against future infection. In conflict with this process is the ability that many viruses have to mutate their antigens to escape infection...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/4/565 |
| _version_ | 1797539894553214976 |
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| author | Harry N White |
| author_facet | Harry N White |
| author_sort | Harry N White |
| collection | DOAJ |
| description | A central feature of vertebrate immune systems is the ability to form antigen-specific immune memory in response to microbial challenge and so provide protection against future infection. In conflict with this process is the ability that many viruses have to mutate their antigens to escape infection- or vaccine-induced antibody memory responses. Mutable viruses such as dengue virus, influenza virus and of course coronavirus have a major global health impact, exacerbated by this ability to evade immune responses through mutation. There have been several outstanding recent studies on B-cell memory that also shed light on the potential and limitations of antibody memory to protect against viral antigen variation, and so promise to inform new strategies for vaccine design. For the purposes of this review, the current understanding of the different memory B-cell (MBC) populations, and their potential to recognize mutant antigens, will be described prior to some examples from antibody responses against the highly mutable RNA based flaviviruses, influenza virus and SARS-CoV-2. |
| first_indexed | 2024-03-10T12:52:17Z |
| format | Article |
| id | doaj.art-70dd4ef160684977b16ac4b3f6f577c5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:52:17Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-70dd4ef160684977b16ac4b3f6f577c52023-11-21T12:11:35ZengMDPI AGViruses1999-49152021-03-0113456510.3390/v13040565B-Cell Memory Responses to Variant Viral AntigensHarry N White0Department of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UKA central feature of vertebrate immune systems is the ability to form antigen-specific immune memory in response to microbial challenge and so provide protection against future infection. In conflict with this process is the ability that many viruses have to mutate their antigens to escape infection- or vaccine-induced antibody memory responses. Mutable viruses such as dengue virus, influenza virus and of course coronavirus have a major global health impact, exacerbated by this ability to evade immune responses through mutation. There have been several outstanding recent studies on B-cell memory that also shed light on the potential and limitations of antibody memory to protect against viral antigen variation, and so promise to inform new strategies for vaccine design. For the purposes of this review, the current understanding of the different memory B-cell (MBC) populations, and their potential to recognize mutant antigens, will be described prior to some examples from antibody responses against the highly mutable RNA based flaviviruses, influenza virus and SARS-CoV-2.https://www.mdpi.com/1999-4915/13/4/565virus mutationantibodyimmune memoryvaccinedengueinfluenza |
| spellingShingle | Harry N White B-Cell Memory Responses to Variant Viral Antigens Viruses virus mutation antibody immune memory vaccine dengue influenza |
| title | B-Cell Memory Responses to Variant Viral Antigens |
| title_full | B-Cell Memory Responses to Variant Viral Antigens |
| title_fullStr | B-Cell Memory Responses to Variant Viral Antigens |
| title_full_unstemmed | B-Cell Memory Responses to Variant Viral Antigens |
| title_short | B-Cell Memory Responses to Variant Viral Antigens |
| title_sort | b cell memory responses to variant viral antigens |
| topic | virus mutation antibody immune memory vaccine dengue influenza |
| url | https://www.mdpi.com/1999-4915/13/4/565 |
| work_keys_str_mv | AT harrynwhite bcellmemoryresponsestovariantviralantigens |