Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature
The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a major operation with the associated requirement for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/31/2/80 |
| _version_ | 1797298487448043520 |
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| author | Todd J. Robinson Kaelyn Cummins Allan Tsung |
| author_facet | Todd J. Robinson Kaelyn Cummins Allan Tsung |
| author_sort | Todd J. Robinson |
| collection | DOAJ |
| description | The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a major operation with the associated requirement for postoperative immunosuppression. With improvements in chemotherapy options, a certain subset of patients can experience stable disease for years, which has prompted investigation into the role of liver transplant in these patients. Several recent studies have shown promising results in well-selected patients, with posttransplant survival approaching that of liver transplant recipients for other diseases. Here, we present a review of the data and current protocols for liver transplant for unresectable CRLM. |
| first_indexed | 2024-03-07T22:36:35Z |
| format | Article |
| id | doaj.art-70dd6845b4494a69a7d28b68adc3a3dd |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-07T22:36:35Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-70dd6845b4494a69a7d28b68adc3a3dd2024-02-23T15:13:28ZengMDPI AGCurrent Oncology1198-00521718-77292024-02-013121079109010.3390/curroncol31020080Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current LiteratureTodd J. Robinson0Kaelyn Cummins1Allan Tsung2Department of Surgery, University of Virginia, 1215 Lee Street, Charlottesville, VA 22908, USADepartment of Surgery, University of Virginia, 1215 Lee Street, Charlottesville, VA 22908, USADepartment of Surgery, University of Virginia, 1215 Lee Street, Charlottesville, VA 22908, USAThe treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a major operation with the associated requirement for postoperative immunosuppression. With improvements in chemotherapy options, a certain subset of patients can experience stable disease for years, which has prompted investigation into the role of liver transplant in these patients. Several recent studies have shown promising results in well-selected patients, with posttransplant survival approaching that of liver transplant recipients for other diseases. Here, we present a review of the data and current protocols for liver transplant for unresectable CRLM.https://www.mdpi.com/1718-7729/31/2/80liver transplantliver tumoroncology |
| spellingShingle | Todd J. Robinson Kaelyn Cummins Allan Tsung Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature Current Oncology liver transplant liver tumor oncology |
| title | Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature |
| title_full | Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature |
| title_fullStr | Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature |
| title_full_unstemmed | Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature |
| title_short | Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature |
| title_sort | liver transplantation for unresectable colorectal liver metastasis perspective and review of current literature |
| topic | liver transplant liver tumor oncology |
| url | https://www.mdpi.com/1718-7729/31/2/80 |
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