Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome
Abstract Introduction Previous studies found subthalamic nucleus deep brain stimulation (STN‐DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN‐DBS for Tourette's syndrome (TS). Globus pallid...
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1450 |
| _version_ | 1828761663557337088 |
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| author | Guan‐Yu Zhu Xin‐Yi Geng Rui‐Li Zhang Ying‐Chuan Chen Yu‐Ye Liu Shou‐Yan Wang Jian‐Guo Zhang |
| author_facet | Guan‐Yu Zhu Xin‐Yi Geng Rui‐Li Zhang Ying‐Chuan Chen Yu‐Ye Liu Shou‐Yan Wang Jian‐Guo Zhang |
| author_sort | Guan‐Yu Zhu |
| collection | DOAJ |
| description | Abstract Introduction Previous studies found subthalamic nucleus deep brain stimulation (STN‐DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN‐DBS for Tourette's syndrome (TS). Globus pallidus interna (GPi)‐DBS is the one of the most common targets for TS. So, this paper aims to investigate the neural oscillations in STN and GPi as well as the DBS effect between these two targets in same patients. Methods The local field potentials (LFPs) were simultaneously recorded from the bilateral GPi and STN in four patients with TS. The LFPs were decomposed into neural oscillations, and the frequency and time–frequency characteristics of the neural oscillations were analyzed across the conditions of resting, poststimulation, and movement. Results No difference of resting LFP was found between the two targets. The poststimulation period spectral power revealed the high beta and gamma oscillations were recovered after GPi‐DBS but remained attenuated after STN‐DBS. The STN beta oscillation has fewer changes during tics than voluntary movement, and the gamma oscillation was elevated when the tics appeared. Conclusion The high beta and gamma oscillations in GPi restored after GPi‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS. |
| first_indexed | 2024-12-11T01:32:33Z |
| format | Article |
| id | doaj.art-70deded4858141ad9018d41eb7f0892a |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-11T01:32:33Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-70deded4858141ad9018d41eb7f0892a2022-12-22T01:25:19ZengWileyBrain and Behavior2162-32792019-12-01912n/an/a10.1002/brb3.1450Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndromeGuan‐Yu Zhu0Xin‐Yi Geng1Rui‐Li Zhang2Ying‐Chuan Chen3Yu‐Ye Liu4Shou‐Yan Wang5Jian‐Guo Zhang6Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaInstitute of Science and Technology for Brain‐Inspired Intelligence Fudan University Shanghai ChinaInstitute of Science and Technology for Brain‐Inspired Intelligence Fudan University Shanghai ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaInstitute of Science and Technology for Brain‐Inspired Intelligence Fudan University Shanghai ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaAbstract Introduction Previous studies found subthalamic nucleus deep brain stimulation (STN‐DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN‐DBS for Tourette's syndrome (TS). Globus pallidus interna (GPi)‐DBS is the one of the most common targets for TS. So, this paper aims to investigate the neural oscillations in STN and GPi as well as the DBS effect between these two targets in same patients. Methods The local field potentials (LFPs) were simultaneously recorded from the bilateral GPi and STN in four patients with TS. The LFPs were decomposed into neural oscillations, and the frequency and time–frequency characteristics of the neural oscillations were analyzed across the conditions of resting, poststimulation, and movement. Results No difference of resting LFP was found between the two targets. The poststimulation period spectral power revealed the high beta and gamma oscillations were recovered after GPi‐DBS but remained attenuated after STN‐DBS. The STN beta oscillation has fewer changes during tics than voluntary movement, and the gamma oscillation was elevated when the tics appeared. Conclusion The high beta and gamma oscillations in GPi restored after GPi‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS.https://doi.org/10.1002/brb3.1450deep brain stimulationglobus pallidus internalocal field potentialsubthalamic nucleusTourette's syndrome |
| spellingShingle | Guan‐Yu Zhu Xin‐Yi Geng Rui‐Li Zhang Ying‐Chuan Chen Yu‐Ye Liu Shou‐Yan Wang Jian‐Guo Zhang Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome Brain and Behavior deep brain stimulation globus pallidus interna local field potential subthalamic nucleus Tourette's syndrome |
| title | Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome |
| title_full | Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome |
| title_fullStr | Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome |
| title_full_unstemmed | Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome |
| title_short | Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome |
| title_sort | deep brain stimulation modulates pallidal and subthalamic neural oscillations in tourette s syndrome |
| topic | deep brain stimulation globus pallidus interna local field potential subthalamic nucleus Tourette's syndrome |
| url | https://doi.org/10.1002/brb3.1450 |
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