The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance
Advances in functional imaging are supporting neurosurgery and radiotherapy for glioblastoma, which still remains the most aggressive brain tumor with poor prognosis. The typical infiltration pattern of glioblastoma, which impedes a complete surgical resection, is coupled with a high rate of invasiv...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/10/2860 |
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| author | Filippo Torrisi Nunzio Vicario Federica M. Spitale Francesco P. Cammarata Luigi Minafra Lucia Salvatorelli Giorgio Russo Giacomo Cuttone Samuel Valable Rosario Gulino Gaetano Magro Rosalba Parenti |
| author_facet | Filippo Torrisi Nunzio Vicario Federica M. Spitale Francesco P. Cammarata Luigi Minafra Lucia Salvatorelli Giorgio Russo Giacomo Cuttone Samuel Valable Rosario Gulino Gaetano Magro Rosalba Parenti |
| author_sort | Filippo Torrisi |
| collection | DOAJ |
| description | Advances in functional imaging are supporting neurosurgery and radiotherapy for glioblastoma, which still remains the most aggressive brain tumor with poor prognosis. The typical infiltration pattern of glioblastoma, which impedes a complete surgical resection, is coupled with a high rate of invasiveness and radioresistance, thus further limiting efficient therapy, leading to inevitable and fatal recurrences. Hypoxia is of crucial importance in gliomagenesis and, besides reducing radiotherapy efficacy, also induces cellular and molecular mediators that foster proliferation and invasion. In this review, we aimed at analyzing the biological mechanism of glioblastoma invasiveness and radioresistance in hypoxic niches of glioblastoma. We also discussed the link between hypoxia and radiation-induced radioresistance with activation of SRC proto-oncogene non-receptor tyrosine kinase, prospecting potential strategies to overcome the current limitation in glioblastoma treatment. |
| first_indexed | 2024-03-10T15:50:45Z |
| format | Article |
| id | doaj.art-70df7fe6391e49e1aceb2267260a1771 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:50:45Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-70df7fe6391e49e1aceb2267260a17712023-11-20T16:04:31ZengMDPI AGCancers2072-66942020-10-011210286010.3390/cancers12102860The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and RadioresistanceFilippo Torrisi0Nunzio Vicario1Federica M. Spitale2Francesco P. Cammarata3Luigi Minafra4Lucia Salvatorelli5Giorgio Russo6Giacomo Cuttone7Samuel Valable8Rosario Gulino9Gaetano Magro10Rosalba Parenti11Department of Biomedical and Biotechnological Sciences (BIOMETEC), Section of Physiology, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), Section of Physiology, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), Section of Physiology, University of Catania, 95123 Catania, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, ItalyDepartment G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele” Anatomic Pathology, University of Catania, 95125 Catania, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, ItalyNational Laboratory of South, National Institute for Nuclear Physics (LNS-INFN), 95125 Catania, ItalyISTCT/CERVOxy Group, GIP Cyceron, CEA, CNRS, Normandie Université, UNICAEN, 14074 Caen, FranceDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), Section of Physiology, University of Catania, 95123 Catania, ItalyDepartment G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele” Anatomic Pathology, University of Catania, 95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), Section of Physiology, University of Catania, 95123 Catania, ItalyAdvances in functional imaging are supporting neurosurgery and radiotherapy for glioblastoma, which still remains the most aggressive brain tumor with poor prognosis. The typical infiltration pattern of glioblastoma, which impedes a complete surgical resection, is coupled with a high rate of invasiveness and radioresistance, thus further limiting efficient therapy, leading to inevitable and fatal recurrences. Hypoxia is of crucial importance in gliomagenesis and, besides reducing radiotherapy efficacy, also induces cellular and molecular mediators that foster proliferation and invasion. In this review, we aimed at analyzing the biological mechanism of glioblastoma invasiveness and radioresistance in hypoxic niches of glioblastoma. We also discussed the link between hypoxia and radiation-induced radioresistance with activation of SRC proto-oncogene non-receptor tyrosine kinase, prospecting potential strategies to overcome the current limitation in glioblastoma treatment.https://www.mdpi.com/2072-6694/12/10/2860GlioblastomahypoxiaradioresistanceinvasionSRC tyrosine kinasetargeted therapy |
| spellingShingle | Filippo Torrisi Nunzio Vicario Federica M. Spitale Francesco P. Cammarata Luigi Minafra Lucia Salvatorelli Giorgio Russo Giacomo Cuttone Samuel Valable Rosario Gulino Gaetano Magro Rosalba Parenti The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance Cancers Glioblastoma hypoxia radioresistance invasion SRC tyrosine kinase targeted therapy |
| title | The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance |
| title_full | The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance |
| title_fullStr | The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance |
| title_full_unstemmed | The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance |
| title_short | The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance |
| title_sort | role of hypoxia and src tyrosine kinase in glioblastoma invasiveness and radioresistance |
| topic | Glioblastoma hypoxia radioresistance invasion SRC tyrosine kinase targeted therapy |
| url | https://www.mdpi.com/2072-6694/12/10/2860 |
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