Stabilization of Tc-99m radiopharmaceuticals by chemical additives
The reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold) kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9% NaCl). The conditions of the storag...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2001-01-01
|
| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2001/0352-51390109591V.pdf |
| _version_ | 1819240373707341824 |
|---|---|
| author | Vučina Jurij Vukičević Nadežda |
| author_facet | Vučina Jurij Vukičević Nadežda |
| author_sort | Vučina Jurij |
| collection | DOAJ |
| description | The reliability and applicability of the preparation of the three, for
nuclear medicine very important, 99mTc-radiopharmaceuticals from the
inactive (technetium-cold) kit solutions were tested. Each examined
commercial kit was dissolved in saline (0.9% NaCl). The conditions of the
storage of the inactive kit solutions till labeling were examined. The main
problem is the stablity of the reductant stannous ions which is very
difficult to predict. To stabilize and ensure a good quality of the labeled
radiopharmaceuticals, ascorbic or gentisic acid were added. It was found
that the best results were obtained by keeping the samples frozen at -20ºC.
Both stabilizers can be used but for an effective protection much lower
concentrations of ascorbic acid are needed. Its concentrations of 12-60
μg/ml of the kit, stabilized dimercaptosuccinate (DMS) and pyrophosphate
(PyP) for about 7-8 days. The solution of 2,3-dicarboxypropane-
1,1-diphosphonate (DPD) was found to be stable even without the stabilizer.
This could be attributed probably to the chemical nature of this complex.
However, in routine praxis the applied procedure demands great care and
personel very experienced in radiopharmacy. |
| first_indexed | 2024-12-23T14:06:59Z |
| format | Article |
| id | doaj.art-70e19e9ef25d433881440de0ce0ab318 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-23T14:06:59Z |
| publishDate | 2001-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-70e19e9ef25d433881440de0ce0ab3182022-12-21T17:44:09ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212001-01-0166959159610.2298/JSC0109591V0352-51390109591VStabilization of Tc-99m radiopharmaceuticals by chemical additivesVučina Jurij0Vukičević Nadežda1Vinča Institute of Nuclear Sciences, Laboratory for Radioisotopes, BelgradeVinča Institute of Nuclear Sciences, Laboratory for Radioisotopes, BelgradeThe reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold) kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9% NaCl). The conditions of the storage of the inactive kit solutions till labeling were examined. The main problem is the stablity of the reductant stannous ions which is very difficult to predict. To stabilize and ensure a good quality of the labeled radiopharmaceuticals, ascorbic or gentisic acid were added. It was found that the best results were obtained by keeping the samples frozen at -20ºC. Both stabilizers can be used but for an effective protection much lower concentrations of ascorbic acid are needed. Its concentrations of 12-60 μg/ml of the kit, stabilized dimercaptosuccinate (DMS) and pyrophosphate (PyP) for about 7-8 days. The solution of 2,3-dicarboxypropane- 1,1-diphosphonate (DPD) was found to be stable even without the stabilizer. This could be attributed probably to the chemical nature of this complex. However, in routine praxis the applied procedure demands great care and personel very experienced in radiopharmacy.http://www.doiserbia.nb.rs/img/doi/0352-5139/2001/0352-51390109591V.pdfradiopharmaceuticalstechnetium-99mdimercaptosuccinatedicarboxypropane diphosphonatepyrophosphate |
| spellingShingle | Vučina Jurij Vukičević Nadežda Stabilization of Tc-99m radiopharmaceuticals by chemical additives Journal of the Serbian Chemical Society radiopharmaceuticals technetium-99m dimercaptosuccinate dicarboxypropane diphosphonate pyrophosphate |
| title | Stabilization of Tc-99m radiopharmaceuticals by chemical additives |
| title_full | Stabilization of Tc-99m radiopharmaceuticals by chemical additives |
| title_fullStr | Stabilization of Tc-99m radiopharmaceuticals by chemical additives |
| title_full_unstemmed | Stabilization of Tc-99m radiopharmaceuticals by chemical additives |
| title_short | Stabilization of Tc-99m radiopharmaceuticals by chemical additives |
| title_sort | stabilization of tc 99m radiopharmaceuticals by chemical additives |
| topic | radiopharmaceuticals technetium-99m dimercaptosuccinate dicarboxypropane diphosphonate pyrophosphate |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2001/0352-51390109591V.pdf |
| work_keys_str_mv | AT vucinajurij stabilizationoftc99mradiopharmaceuticalsbychemicaladditives AT vukicevicnadezda stabilizationoftc99mradiopharmaceuticalsbychemicaladditives |