Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD. They display progressive motor deficits, abnormal cellular accumulation of α-syn, and de...

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Bibliographic Details
Main Authors: Nicola J Platt, Suzana Gispert, Georg Auburger, Stephanie J Cragg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22570709/pdf/?tool=EBI

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