Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood
Abstract Background Epidemiological studies have demonstrated a relationship between cognitive function in youth and the future risk of death. Less is known regarding the relationship with diabetes related death. This study assessed the relationship between cognitive function in late adolescence and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-018-0798-5 |
| _version_ | 1818595932528181248 |
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| author | Gilad Twig Amir Tirosh Estela Derazne Ziona Haklai Nehama Goldberger Arnon Afek Hertzel C. Gerstein Jeremy D. Kark Tali Cukierman-Yaffe |
| author_facet | Gilad Twig Amir Tirosh Estela Derazne Ziona Haklai Nehama Goldberger Arnon Afek Hertzel C. Gerstein Jeremy D. Kark Tali Cukierman-Yaffe |
| author_sort | Gilad Twig |
| collection | DOAJ |
| description | Abstract Background Epidemiological studies have demonstrated a relationship between cognitive function in youth and the future risk of death. Less is known regarding the relationship with diabetes related death. This study assessed the relationship between cognitive function in late adolescence and the risk for diabetes, cardiovascular- (CVD) and all-cause mortality in adulthood. Methods This retrospective study linked data from 2,277,188 16–19 year olds who had general intelligence tests (GIT) conducted during pre-military recruitment assessment with cause of death as coded by the Israel Central Bureau of Statistics. The associations between cognitive function and cause-specific mortality were assessed using Cox models. Results There were 31,268 deaths that were recorded during 41,916,603 person-years of follow-up, with a median follow-up of 19.2 (IQR 10.7, 29.5) years. 3068, 1443, 514 and 457 deaths were attributed to CVD, CHD, stroke, and diabetes, respectively. Individuals in the lowest GIT vs. highest GIT quintiles in unadjusted models had the highest risk for all-cause mortality (HR 1.84, 95% CI 1.78, 1.91), total CVD (HR 3.32, 95% CI 2.93, 3.75), CHD (HR 3.49 95% CI 2.92, 4.18), stroke (HR 3.96 95% CI 2.85, 5.5) and diabetes-related (HR 6.96 95% CI 4.68, 10.36) mortality. These HRs were attenuated following adjustment for age, sex, birth year, body-mass index, residential socioeconomic status, education and country of origin for all-cause (HR 1.23, 95% CI 1.17, 1.28), CVD (HR 1.76, 95% CI 1.52, 2.04), CHD (HR 1.7 95% CI 1.37, 2.11), stroke (HR 2.03, 95% CI 1.39, 2.98) and diabetes-related (HR 3.14 95% CI 2.00, 4.94) mortality. Results persisted in a sensitivity analyses limited to participants with unimpaired health at baseline and that accounted competing risk. Conclusions This analysis of over 2 million demonstrates a strong relationship between cognitive function at youth and the risk for diabetes, all-cause and CVD-related mortality independent of adolescent obesity. |
| first_indexed | 2024-12-16T11:23:52Z |
| format | Article |
| id | doaj.art-70e63dfb7f424f3898ca4d999260bbe8 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-16T11:23:52Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-70e63dfb7f424f3898ca4d999260bbe82022-12-21T22:33:25ZengBMCCardiovascular Diabetology1475-28402018-12-0117111010.1186/s12933-018-0798-5Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthoodGilad Twig0Amir Tirosh1Estela Derazne2Ziona Haklai3Nehama Goldberger4Arnon Afek5Hertzel C. Gerstein6Jeremy D. Kark7Tali Cukierman-Yaffe8Department of Medicine, Sheba Medical CenterThe Sackler School of Medicine, Tel Aviv UniversityThe Israel Defense Forces Medical CorpsIsrael Ministry of HealthIsrael Ministry of HealthDepartment of Medicine, Sheba Medical CenterDivision of Endocrinology & Metabolism, and Population Health Research Institute, McMaster University & Hamilton Health SciencesHebrew University-Hadassah School of Public Health and Community MedicineThe Sackler School of Medicine, Tel Aviv UniversityAbstract Background Epidemiological studies have demonstrated a relationship between cognitive function in youth and the future risk of death. Less is known regarding the relationship with diabetes related death. This study assessed the relationship between cognitive function in late adolescence and the risk for diabetes, cardiovascular- (CVD) and all-cause mortality in adulthood. Methods This retrospective study linked data from 2,277,188 16–19 year olds who had general intelligence tests (GIT) conducted during pre-military recruitment assessment with cause of death as coded by the Israel Central Bureau of Statistics. The associations between cognitive function and cause-specific mortality were assessed using Cox models. Results There were 31,268 deaths that were recorded during 41,916,603 person-years of follow-up, with a median follow-up of 19.2 (IQR 10.7, 29.5) years. 3068, 1443, 514 and 457 deaths were attributed to CVD, CHD, stroke, and diabetes, respectively. Individuals in the lowest GIT vs. highest GIT quintiles in unadjusted models had the highest risk for all-cause mortality (HR 1.84, 95% CI 1.78, 1.91), total CVD (HR 3.32, 95% CI 2.93, 3.75), CHD (HR 3.49 95% CI 2.92, 4.18), stroke (HR 3.96 95% CI 2.85, 5.5) and diabetes-related (HR 6.96 95% CI 4.68, 10.36) mortality. These HRs were attenuated following adjustment for age, sex, birth year, body-mass index, residential socioeconomic status, education and country of origin for all-cause (HR 1.23, 95% CI 1.17, 1.28), CVD (HR 1.76, 95% CI 1.52, 2.04), CHD (HR 1.7 95% CI 1.37, 2.11), stroke (HR 2.03, 95% CI 1.39, 2.98) and diabetes-related (HR 3.14 95% CI 2.00, 4.94) mortality. Results persisted in a sensitivity analyses limited to participants with unimpaired health at baseline and that accounted competing risk. Conclusions This analysis of over 2 million demonstrates a strong relationship between cognitive function at youth and the risk for diabetes, all-cause and CVD-related mortality independent of adolescent obesity.http://link.springer.com/article/10.1186/s12933-018-0798-5AdolescenceCognitive performanceDiabetesMortalityIsraelis |
| spellingShingle | Gilad Twig Amir Tirosh Estela Derazne Ziona Haklai Nehama Goldberger Arnon Afek Hertzel C. Gerstein Jeremy D. Kark Tali Cukierman-Yaffe Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood Cardiovascular Diabetology Adolescence Cognitive performance Diabetes Mortality Israelis |
| title | Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| title_full | Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| title_fullStr | Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| title_full_unstemmed | Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| title_short | Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| title_sort | cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood |
| topic | Adolescence Cognitive performance Diabetes Mortality Israelis |
| url | http://link.springer.com/article/10.1186/s12933-018-0798-5 |
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