| Summary: | The presence of microorganisms, specifically the <i>Escherichia coli</i>, in drinking water is of global concern. This is mainly due to the health implications of these pathogens. Several conventional methods have been developed for their removal; however, this pathogen is still found in most drinking water. In the continuous quest for a more effective removal approach, photocatalysis has been considered as an alternative method for the elimination of pathogens including <i>E. coli</i> from water. Photocatalysis has many advantages compared to the conventional methods. It offers the advantage of non-toxicity and utilizes the energy from sunlight, thereby making it a completely green route. Since most photocatalysts could only be active in the ultraviolet region of the solar spectrum, which is less than 5% of the entire spectrum, the challenge associated with photocatalysis is the design of a system for the effective harvest and complete utilization of the solar energy for the photocatalytic process. In this review, different photocatalysts for effective inactivation of <i>E. coli</i> and the mechanism involved in the process were reviewed. Various strategies that have been adopted in order to modulate the band gap energy of these photocatalysts have been explored. In addition, different methods of estimating and detecting <i>E. coli</i> in drinking water were presented. Furthermore, different photocatalytic reactor designs for photocatalytic inactivation of <i>E. coli</i> were examined. Finally, the kinetics of <i>E. coli</i> inactivation was discussed.
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