EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes
Eva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet al...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6181 |
| _version_ | 1797530944679182336 |
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| author | Shizhen Zhao Honggang Wang |
| author_facet | Shizhen Zhao Honggang Wang |
| author_sort | Shizhen Zhao |
| collection | DOAJ |
| description | Eva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet alpha-cell functions, acute liver failure, and hepatitis B virus replication. However, the related mechanisms are not fully clear. Autophagy is a process in which cells transfer pathogens, abnormal proteins and organelles to lysosomes for degradation. It plays an important role in various physiological and pathological processes, including cancer, aging, neurodegeneration, infection, heart disease, development, cell differentiation and nutritional starvation. Recently, there are many studies on the important role of EVA1A in many physiological and pathological processes by regulating autophagy. However, the related molecular mechanisms need further study. Therefore, we summarize the above-mentioned researches about the role of EVA1A in physiological and pathological processes through regulating autophagy in order to provide theoretical basis for future researches. |
| first_indexed | 2024-03-10T10:37:09Z |
| format | Article |
| id | doaj.art-70e8aeb5bdae4e178625a382a875d8bd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:37:09Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-70e8aeb5bdae4e178625a382a875d8bd2023-11-21T23:13:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212618110.3390/ijms22126181EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological ProcessesShizhen Zhao0Honggang Wang1Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, ChinaHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, ChinaEva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet alpha-cell functions, acute liver failure, and hepatitis B virus replication. However, the related mechanisms are not fully clear. Autophagy is a process in which cells transfer pathogens, abnormal proteins and organelles to lysosomes for degradation. It plays an important role in various physiological and pathological processes, including cancer, aging, neurodegeneration, infection, heart disease, development, cell differentiation and nutritional starvation. Recently, there are many studies on the important role of EVA1A in many physiological and pathological processes by regulating autophagy. However, the related molecular mechanisms need further study. Therefore, we summarize the above-mentioned researches about the role of EVA1A in physiological and pathological processes through regulating autophagy in order to provide theoretical basis for future researches.https://www.mdpi.com/1422-0067/22/12/6181EVA1Aautophagyapoptosistumorliver injury |
| spellingShingle | Shizhen Zhao Honggang Wang EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes International Journal of Molecular Sciences EVA1A autophagy apoptosis tumor liver injury |
| title | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
| title_full | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
| title_fullStr | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
| title_full_unstemmed | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
| title_short | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
| title_sort | eva1a plays an important role by regulating autophagy in physiological and pathological processes |
| topic | EVA1A autophagy apoptosis tumor liver injury |
| url | https://www.mdpi.com/1422-0067/22/12/6181 |
| work_keys_str_mv | AT shizhenzhao eva1aplaysanimportantrolebyregulatingautophagyinphysiologicalandpathologicalprocesses AT honggangwang eva1aplaysanimportantrolebyregulatingautophagyinphysiologicalandpathologicalprocesses |