Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study
BackgroundIntrahepatic cholangiocarcinoma is a highly malignant and invasive cancer originating from biliary epithelial cells. The current study was designed to evaluate the feasibility, safety, and clinical outcomes of laparoscopic anatomical hepatectomy in patients with intrahepatic cholangiocarci...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1003948/full |
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| author | Jianlei Wang Delin Ma Gang Du Baokun An Tong Xia Tao Zhou Qingmei Sun Fengyue Liu Yadong Wang Deling Sui Xiangyu Zhai Bin Jin |
| author_facet | Jianlei Wang Delin Ma Gang Du Baokun An Tong Xia Tao Zhou Qingmei Sun Fengyue Liu Yadong Wang Deling Sui Xiangyu Zhai Bin Jin |
| author_sort | Jianlei Wang |
| collection | DOAJ |
| description | BackgroundIntrahepatic cholangiocarcinoma is a highly malignant and invasive cancer originating from biliary epithelial cells. The current study was designed to evaluate the feasibility, safety, and clinical outcomes of laparoscopic anatomical hepatectomy in patients with intrahepatic cholangiocarcinoma.MethodsAfter screening, 95 patients who underwent anatomical hepatectomy for intrahepatic cholangiocarcinoma at our center were enrolled and divided into two groups according to the surgical approach; the baseline characteristics, pathological findings, surgical outcomes, and long-term outcomes were compared. Moreover, univariate and multivariate analyses were performed to identify independent prognostic factors for overall survival (OS) and disease-free survival (DFS).ResultsThere were no significant differences in baseline characteristics or pathological findings between the two groups. Regarding short-term outcomes, the intraoperative blood loss, incision length, and length of postoperative hospital stay were more favorable in the laparoscopic anatomical hepatectomy group than the open anatomical hepatectomy group (P < 0.05). The two groups differed significantly in the extent of liver resection, with a lower lymph node dissection rate and lymph node yield in the laparoscopic anatomical hepatectomy group (P < 0.05). Furthermore, the postoperative complication rate was similar in the two groups (P > 0.05). The median postoperative follow-up times were 10.7 and 13.8 months in the laparoscopic anatomical hepatectomy and open anatomical hepatectomy groups, respectively. Regarding the long-term follow-up results, OS and DFS were similar in the two groups (P > 0.05). On multivariate analysis, the independent prognostic factors for OS were CA-199, CEA, HGB, tumor diameter, and T stage, and those for DFS were CA-199 (P < 0.05), and T stage (P < 0.05).Conclusionlaparoscopic anatomical hepatectomy for intrahepatic cholangiocarcinoma is safe and feasible when performed by experienced surgeons. Compared with open anatomical hepatectomy, laparoscopic anatomical hepatectomy provides better short-term outcomes and a comparable long-term prognosis. |
| first_indexed | 2024-04-13T23:53:47Z |
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| id | doaj.art-70e8b8c578044eaa9bb23c4f8ded5f0a |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-13T23:53:47Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Surgery |
| spelling | doaj.art-70e8b8c578044eaa9bb23c4f8ded5f0a2022-12-22T02:24:00ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-10-01910.3389/fsurg.2022.10039481003948Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort studyJianlei Wang0Delin Ma1Gang Du2Baokun An3Tong Xia4Tao Zhou5Qingmei Sun6Fengyue Liu7Yadong Wang8Deling Sui9Xiangyu Zhai10Bin Jin11Department of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, ChinaDepartment of Organ Transplantation, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Gastroenterology, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of Anesthesia, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of Organ Transplantation, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of Organ Transplantation, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of General Surgery, The Second People's Hospital of Liaocheng, Liaocheng, ChinaDepartment of General Surgery, Second Hospital of Shandong University, Jinan, ChinaDepartment of Organ Transplantation, Qilu Hospital, Shandong University, Jinan, ChinaBackgroundIntrahepatic cholangiocarcinoma is a highly malignant and invasive cancer originating from biliary epithelial cells. The current study was designed to evaluate the feasibility, safety, and clinical outcomes of laparoscopic anatomical hepatectomy in patients with intrahepatic cholangiocarcinoma.MethodsAfter screening, 95 patients who underwent anatomical hepatectomy for intrahepatic cholangiocarcinoma at our center were enrolled and divided into two groups according to the surgical approach; the baseline characteristics, pathological findings, surgical outcomes, and long-term outcomes were compared. Moreover, univariate and multivariate analyses were performed to identify independent prognostic factors for overall survival (OS) and disease-free survival (DFS).ResultsThere were no significant differences in baseline characteristics or pathological findings between the two groups. Regarding short-term outcomes, the intraoperative blood loss, incision length, and length of postoperative hospital stay were more favorable in the laparoscopic anatomical hepatectomy group than the open anatomical hepatectomy group (P < 0.05). The two groups differed significantly in the extent of liver resection, with a lower lymph node dissection rate and lymph node yield in the laparoscopic anatomical hepatectomy group (P < 0.05). Furthermore, the postoperative complication rate was similar in the two groups (P > 0.05). The median postoperative follow-up times were 10.7 and 13.8 months in the laparoscopic anatomical hepatectomy and open anatomical hepatectomy groups, respectively. Regarding the long-term follow-up results, OS and DFS were similar in the two groups (P > 0.05). On multivariate analysis, the independent prognostic factors for OS were CA-199, CEA, HGB, tumor diameter, and T stage, and those for DFS were CA-199 (P < 0.05), and T stage (P < 0.05).Conclusionlaparoscopic anatomical hepatectomy for intrahepatic cholangiocarcinoma is safe and feasible when performed by experienced surgeons. Compared with open anatomical hepatectomy, laparoscopic anatomical hepatectomy provides better short-term outcomes and a comparable long-term prognosis.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1003948/fulllaparoscopic anatomical hepatectomyopen anatomical hepatectomyoutcomesoverall survivaldisease-Free survival |
| spellingShingle | Jianlei Wang Delin Ma Gang Du Baokun An Tong Xia Tao Zhou Qingmei Sun Fengyue Liu Yadong Wang Deling Sui Xiangyu Zhai Bin Jin Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study Frontiers in Surgery laparoscopic anatomical hepatectomy open anatomical hepatectomy outcomes overall survival disease-Free survival |
| title | Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study |
| title_full | Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study |
| title_fullStr | Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study |
| title_full_unstemmed | Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study |
| title_short | Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study |
| title_sort | laparoscopic vs open anatomical hepatectomy for intrahepatic cholangiocarcinoma a retrospective cohort study |
| topic | laparoscopic anatomical hepatectomy open anatomical hepatectomy outcomes overall survival disease-Free survival |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1003948/full |
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