Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate
Nonsyndromic cleft lip with/without cleft palate is a common congenital birth defect of the maxillofacial region. The pathogenic mechanism is related to the interaction of genes and environmental factors. At present, there are many studies on genes, and genome-wide association analysis has found tha...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2021-01-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2021.01.010 |
| _version_ | 1819121972900003840 |
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| author | WANG Shikui SONG Qinggao LAN Xuejiao |
| author_facet | WANG Shikui SONG Qinggao LAN Xuejiao |
| author_sort | WANG Shikui |
| collection | DOAJ |
| description | Nonsyndromic cleft lip with/without cleft palate is a common congenital birth defect of the maxillofacial region. The pathogenic mechanism is related to the interaction of genes and environmental factors. At present, there are many studies on genes, and genome-wide association analysis has found that the new susceptibility gene v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is associated with the development of nonsyndromic cleft lip with/without cleft palate. This paper reviews the research progress on the correlation between single nucletide polymorphism(SNPs) in MAFB and nonsyndromic cleft lip with/without cleft palate. The results of this review reveal how the MAFB gene is expressed and differentiated in various cell types and plays an important role in maintaining the development of various organs, such as the brain, pancreas, and parathyroid glands. The MAFB gene is significantly associated with the occurrence of nonsyndromic cleft lip with/without cleft palate in the Asian population. rs13041247, rs11696257, rs17820943 and other teratopoietic single nucleotide loci are the most commonly studied teratopoietic single nucleotide loci, and the research conclusions on the correlation between SNPs in MAFB genes are obviously different in different populations. The interaction between the MAFB gene and other susceptibility genes leads to the occurrence of nonsyndromic cleft lip with/without cleft palate; nevertheless, more in-depth research is needed on specific mechanisms and approaches based on the relationship between these two factors |
| first_indexed | 2024-12-22T06:45:03Z |
| format | Article |
| id | doaj.art-70e974412ebd431bb01ac84b539320ca |
| institution | Directory Open Access Journal |
| issn | 2096-1456 2096-1456 |
| language | zho |
| last_indexed | 2024-12-22T06:45:03Z |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-70e974412ebd431bb01ac84b539320ca2022-12-21T18:35:19ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562096-14562021-01-01291616410.12016/j.issn.2096⁃1456.2021.01.010Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palateWANG Shikui0 SONG Qinggao1LAN Xuejiao21.Zunyi Medical University 2.Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Zunyi Medical University1.Zunyi Medical University 2.Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Zunyi Medical University1.Zunyi Medical University 2.Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Zunyi Medical UniversityNonsyndromic cleft lip with/without cleft palate is a common congenital birth defect of the maxillofacial region. The pathogenic mechanism is related to the interaction of genes and environmental factors. At present, there are many studies on genes, and genome-wide association analysis has found that the new susceptibility gene v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is associated with the development of nonsyndromic cleft lip with/without cleft palate. This paper reviews the research progress on the correlation between single nucletide polymorphism(SNPs) in MAFB and nonsyndromic cleft lip with/without cleft palate. The results of this review reveal how the MAFB gene is expressed and differentiated in various cell types and plays an important role in maintaining the development of various organs, such as the brain, pancreas, and parathyroid glands. The MAFB gene is significantly associated with the occurrence of nonsyndromic cleft lip with/without cleft palate in the Asian population. rs13041247, rs11696257, rs17820943 and other teratopoietic single nucleotide loci are the most commonly studied teratopoietic single nucleotide loci, and the research conclusions on the correlation between SNPs in MAFB genes are obviously different in different populations. The interaction between the MAFB gene and other susceptibility genes leads to the occurrence of nonsyndromic cleft lip with/without cleft palate; nevertheless, more in-depth research is needed on specific mechanisms and approaches based on the relationship between these two factorshttp://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2021.01.010non-syndromic cleft lip with/without cleft palatev-maf musculoaponeurotic fibrosarcoma oncogene homolog bgene polymorphismssingle nucleotide polymorphismsrs13041247rs11696257rs17820943 |
| spellingShingle | WANG Shikui SONG Qinggao LAN Xuejiao Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate 口腔疾病防治 non-syndromic cleft lip with/without cleft palate v-maf musculoaponeurotic fibrosarcoma oncogene homolog b gene polymorphisms single nucleotide polymorphisms rs13041247 rs11696257 rs17820943 |
| title | Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate |
| title_full | Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate |
| title_fullStr | Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate |
| title_full_unstemmed | Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate |
| title_short | Research progress on MAFB gene polymorphism and nonsyndromic cleft lip and palate |
| title_sort | research progress on mafb gene polymorphism and nonsyndromic cleft lip and palate |
| topic | non-syndromic cleft lip with/without cleft palate v-maf musculoaponeurotic fibrosarcoma oncogene homolog b gene polymorphisms single nucleotide polymorphisms rs13041247 rs11696257 rs17820943 |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2021.01.010 |
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