Vulnerable COPD patients with comorbidities: the role of roflumilast
Melissa Lipari1,2 Pramodini B Kale-Pradhan1,2 1Department of Pharmacy Practice, Wayne State University; 2St John Hospital and Medical Center, Detroit, MI, USA Abstract: Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved by the US Food and Drug Administration in Febr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-11-01
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| Series: | Therapeutics and Clinical Risk Management |
| Online Access: | http://www.dovepress.com/vulnerable-copd-patients-with-comorbidities-the-role-of-roflumilast-peer-reviewed-article-TCRM |
| _version_ | 1818461849526468608 |
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| author | Lipari M Kale-Pradhan PB |
| author_facet | Lipari M Kale-Pradhan PB |
| author_sort | Lipari M |
| collection | DOAJ |
| description | Melissa Lipari1,2 Pramodini B Kale-Pradhan1,2 1Department of Pharmacy Practice, Wayne State University; 2St John Hospital and Medical Center, Detroit, MI, USA Abstract: Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved by the US Food and Drug Administration in February 2011 for the management of chronic obstructive pulmonary disease (COPD). Literature was retrieved through PubMed using the terms “roflumilast” and “COPD”. Reference citations from publications identified were also reviewed. All articles published in English using the terms “roflumilast” and “COPD” were retrieved. For evaluation of clinical efficacy, published Phase III studies and pooled analyses of Phase III trials were included. In seven published Phase III trials, roflumilast at 500 µg daily showed improvements in lung function as measured by pre- and post-bronchodilator forced expiratory volume in 1 second. Roflumilast appears to be useful in vulnerable patients who are at high risk for exacerbations. Roflumilast was found to be effective when administered alone and with concomitant long-acting bronchodilator therapy in the Caucasian and Asian population. Patients with severe-to-very severe COPD, chronic bronchitis, and frequent history of exacerbations derived the greatest benefit with roflumilast. Compared to the standard of care therapies, roflumilast is more cost-prohibitive. Roflumilast was well tolerated, with the most common adverse events observed in clinical trials being diarrhea, nausea, and headache. Weight loss and increased risk of psychiatric events have also been observed with roflumilast in clinical trials. Roflumilast is a safe and effective option for the treatment of COPD. Keywords: roflumilast, COPD, phosphodiesterase-4 inhibitor |
| first_indexed | 2024-12-14T23:52:41Z |
| format | Article |
| id | doaj.art-70ee8f10332e4740920819e5afda3d3e |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-14T23:52:41Z |
| publishDate | 2014-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-70ee8f10332e4740920819e5afda3d3e2022-12-21T22:43:11ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2014-11-012014default96997619203Vulnerable COPD patients with comorbidities: the role of roflumilastLipari MKale-Pradhan PBMelissa Lipari1,2 Pramodini B Kale-Pradhan1,2 1Department of Pharmacy Practice, Wayne State University; 2St John Hospital and Medical Center, Detroit, MI, USA Abstract: Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved by the US Food and Drug Administration in February 2011 for the management of chronic obstructive pulmonary disease (COPD). Literature was retrieved through PubMed using the terms “roflumilast” and “COPD”. Reference citations from publications identified were also reviewed. All articles published in English using the terms “roflumilast” and “COPD” were retrieved. For evaluation of clinical efficacy, published Phase III studies and pooled analyses of Phase III trials were included. In seven published Phase III trials, roflumilast at 500 µg daily showed improvements in lung function as measured by pre- and post-bronchodilator forced expiratory volume in 1 second. Roflumilast appears to be useful in vulnerable patients who are at high risk for exacerbations. Roflumilast was found to be effective when administered alone and with concomitant long-acting bronchodilator therapy in the Caucasian and Asian population. Patients with severe-to-very severe COPD, chronic bronchitis, and frequent history of exacerbations derived the greatest benefit with roflumilast. Compared to the standard of care therapies, roflumilast is more cost-prohibitive. Roflumilast was well tolerated, with the most common adverse events observed in clinical trials being diarrhea, nausea, and headache. Weight loss and increased risk of psychiatric events have also been observed with roflumilast in clinical trials. Roflumilast is a safe and effective option for the treatment of COPD. Keywords: roflumilast, COPD, phosphodiesterase-4 inhibitorhttp://www.dovepress.com/vulnerable-copd-patients-with-comorbidities-the-role-of-roflumilast-peer-reviewed-article-TCRM |
| spellingShingle | Lipari M Kale-Pradhan PB Vulnerable COPD patients with comorbidities: the role of roflumilast Therapeutics and Clinical Risk Management |
| title | Vulnerable COPD patients with comorbidities: the role of roflumilast |
| title_full | Vulnerable COPD patients with comorbidities: the role of roflumilast |
| title_fullStr | Vulnerable COPD patients with comorbidities: the role of roflumilast |
| title_full_unstemmed | Vulnerable COPD patients with comorbidities: the role of roflumilast |
| title_short | Vulnerable COPD patients with comorbidities: the role of roflumilast |
| title_sort | vulnerable copd patients with comorbidities the role of roflumilast |
| url | http://www.dovepress.com/vulnerable-copd-patients-with-comorbidities-the-role-of-roflumilast-peer-reviewed-article-TCRM |
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