Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)
High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective eff...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Beverages |
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| Online Access: | https://www.mdpi.com/2306-5710/4/4/100 |
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| author | Denise dos Santos Lacerda Mariana Garbin de Almeida Cláudia Teixeira Alyne de Jesus Édison da Silva Pereira Júnior Patrícia Martins Bock João Antônio Pegas Henriques Rosane Gomez Caroline Dani Cláudia Funchal |
| author_facet | Denise dos Santos Lacerda Mariana Garbin de Almeida Cláudia Teixeira Alyne de Jesus Édison da Silva Pereira Júnior Patrícia Martins Bock João Antônio Pegas Henriques Rosane Gomez Caroline Dani Cláudia Funchal |
| author_sort | Denise dos Santos Lacerda |
| collection | DOAJ |
| description | High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects. |
| first_indexed | 2024-04-14T08:19:23Z |
| format | Article |
| id | doaj.art-70efa3e905ac489d9dfbe6fceb92fb6c |
| institution | Directory Open Access Journal |
| issn | 2306-5710 |
| language | English |
| last_indexed | 2024-04-14T08:19:23Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Beverages |
| spelling | doaj.art-70efa3e905ac489d9dfbe6fceb92fb6c2022-12-22T02:04:17ZengMDPI AGBeverages2306-57102018-12-014410010.3390/beverages4040100beverages4040100Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)Denise dos Santos Lacerda0Mariana Garbin de Almeida1Cláudia Teixeira2Alyne de Jesus3Édison da Silva Pereira Júnior4Patrícia Martins Bock5João Antônio Pegas Henriques6Rosane Gomez7Caroline Dani8Cláudia Funchal9Centro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilFaculdades Integradas de Taquara, Taquara, RS, 95612-150, BrazilDepartamento de Biofísica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 91501- 970, BrazilDepartamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90040-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilCentro Universitário Metodista—IPA, Porto Alegre, RS, 90420-060, BrazilHigh-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects.https://www.mdpi.com/2306-5710/4/4/100grape juiceantioxidantshigh-fat dietprotectionobesity |
| spellingShingle | Denise dos Santos Lacerda Mariana Garbin de Almeida Cláudia Teixeira Alyne de Jesus Édison da Silva Pereira Júnior Patrícia Martins Bock João Antônio Pegas Henriques Rosane Gomez Caroline Dani Cláudia Funchal Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) Beverages grape juice antioxidants high-fat diet protection obesity |
| title | Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) |
| title_full | Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) |
| title_fullStr | Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) |
| title_full_unstemmed | Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) |
| title_short | Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety) |
| title_sort | biochemical and physiological parameters in rats fed with high fat diet the protective effect of chronic treatment with purple grape juice bordo variety |
| topic | grape juice antioxidants high-fat diet protection obesity |
| url | https://www.mdpi.com/2306-5710/4/4/100 |
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