Multi-omics analysis reveals a macrophage-related marker gene signature for prognostic prediction, immune landscape, genomic heterogeneity, and drug choices in prostate cancer

Multi-omics analysis reveals a macrophage-related marker gene signature for prognostic prediction, immune landscape, genomic heterogeneity, and drug choices in prostate cancer

IntroductionMacrophages are components of the innate immune system and can play an anti-tumor or pro-tumor role in the tumor microenvironment owing to their high heterogeneity and plasticity. Meanwhile, prostate cancer (PCa) is an immune-sensitive tumor, making it essential to investigate the value...

Full description

Bibliographic Details
Main Authors:	Weian Zhu, Jianjie Wu, Jiongduan Huang, Dongming Xiao, Fengao Li, Chenglun Wu, Xiaojuan Li, Hengda Zeng, Jiayu Zheng, Wenjie Lai, Xingqiao Wen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Immunology
Subjects:	prostate cancer macrophage-related marker gene prognostic signature tumor immunity genomic heterogeneity drug choices
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122670/full

Similar Items

Inflammation-related signature for prognostic prediction, tumor immune, genomic heterogeneity, and drug choices in prostate cancer: Integrated analysis of bulk and single-cell RNA-sequencing
by: Weian Zhu, et al.
Published: (2023-11-01)

Aggrephagy-related gene signature correlates with survival and tumor-associated macrophages in glioma: Insights from single-cell and bulk RNA sequencing
by: Xiaowei Zhang, et al.
Published: (2024-01-01)

Construction and Validation of a Universal Applicable Prognostic Signature for Gastric Cancer Based on Seven Immune-Related Gene Correlated With Tumor Associated Macrophages
by: Junyu Huo, et al.
Published: (2021-06-01)

Bioinformatics reveal macrophages marker genes signature in breast cancer to predict prognosis
by: Ying Li, et al.
Published: (2021-01-01)

Integrated machine learning identifies epithelial cell marker genes for improving outcomes and immunotherapy in prostate cancer
by: Weian Zhu, et al.
Published: (2023-11-01)

Prognostic significance of a 4-lncRNA glycolysis-related signature in oral squamous cell carcinoma
by: Liangyin Wu, et al.
Published: (2022-04-01)

An Aggrephagy-Related LncRNA Signature for the Prognosis of Pancreatic Adenocarcinoma
by: Xueyuan Huang, et al.
Published: (2023-01-01)

Role of alternative splicing signatures in the prognosis of glioblastoma
by: Zu‐cheng Xie, et al.
Published: (2019-12-01)

Systematic and Multi-Omics Prognostic Analysis of Lysine Acetylation Regulators in Glioma
by: Zewei Tu, et al.
Published: (2021-02-01)

Comprehensive analysis of metabolic pathway activity subtypes derived prognostic signature in hepatocellular carcinoma
by: Junyu Huo, et al.
Published: (2023-01-01)

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer
by: Yilin Yan, et al.
Published: (2021-08-01)

A novel exosome-derived prognostic signature and risk stratification for breast cancer based on multi-omics and systematic biological heterogeneity
by: Fei Long, et al.
Published: (2023-01-01)

Identification of the Prognostic Signatures of Glioma With Different PTEN Status
by: Pei Zhang, et al.
Published: (2021-07-01)

A macrophage related signature for predicting prognosis and drug sensitivity in ovarian cancer based on integrative machine learning
by: Bo Zhao, et al.
Published: (2023-10-01)

A Novel Necroptosis-Related Gene Signature in Skin Cutaneous Melanoma Prognosis and Tumor Microenvironment
by: Binyu Song, et al.
Published: (2022-07-01)

Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma
by: Binghua Yang, et al.
Published: (2023-01-01)

Construction and Validation of Novel Diagnostic and Prognostic DNA Methylation Signatures for Hepatocellular Carcinoma
by: Ran Li, et al.
Published: (2020-08-01)

An autophagy‐related long non‐coding RNA signature for glioma
by: Fangkun Luan, et al.
Published: (2019-04-01)

Identification of Lactate-Related Gene Signature for Prediction of Progression and Immunotherapeutic Response in Skin Cutaneous Melanoma
by: Yalin Xie, et al.
Published: (2022-02-01)

A Ferroptosis and Pyroptosis Molecular Subtype-Related Signature Applicable for Prognosis and Immune Microenvironment Estimation in Hepatocellular Carcinoma
by: Junyu Huo, et al.
Published: (2021-11-01)

Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer
by: Pu Wu, et al.
Published: (2021-10-01)

Deep View of HCC Gene Expression Signatures and Their Comparison with Other Cancers
by: Yuquan Qian, et al.
Published: (2022-09-01)

CoMI: consensus mutual information for tissue-specific gene signatures
by: Sing-Han Huang, et al.
Published: (2022-04-01)

An integrative analysis revealing cuproptosis-related lncRNAs signature as a novel prognostic biomarker in hepatocellular carcinoma
by: Xilang Chen, et al.
Published: (2023-02-01)

A Newly Established Cuproptosis-Related Gene Signature for Predicting Prognosis and Immune Infiltration in Uveal Melanoma
by: Wei Huang, et al.
Published: (2023-07-01)

Autophagy-Related Genes and Long Noncoding RNAs Signatures as Predictive Biomarkers for Osteosarcoma Survival
by: Jian Zhang, et al.
Published: (2021-08-01)

Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors
by: Dong Yang, et al.
Published: (2023-09-01)

An immune‐related prognostic signature for predicting breast cancer recurrence
by: Zelin Tian, et al.
Published: (2020-10-01)

Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma
by: Yanpeng Zhang, et al.
Published: (2024-01-01)

Characterization of coagulation-related gene signature to predict prognosis and tumor immune microenvironment in skin cutaneous melanoma
by: Binyu Song, et al.
Published: (2022-08-01)

Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma
by: Jinzhi Lai, et al.
Published: (2022-03-01)

Identification and validation of a five-gene prognostic signature based on bioinformatics analyses in breast cancer
by: Xin-jie Du, et al.
Published: (2023-02-01)

Prognostic and immunological significance of an M1 macrophage-related gene signature in osteosarcoma
by: Xiaoyu Mao, et al.
Published: (2023-07-01)

Construction and Validation of a Reliable Six-Gene Prognostic Signature Based on the TP53 Alteration for Hepatocellular Carcinoma
by: Junyu Huo, et al.
Published: (2021-06-01)

Identification of NAD+ Metabolism-Derived Gene Signatures in Ovarian Cancer Prognosis and Immunotherapy
by: Liang Lin, et al.
Published: (2022-06-01)

Integration of single-cell and bulk RNA sequencing to establish a prognostic signature based on tumor-associated macrophages in colorectal cancer
by: Hua Li, et al.
Published: (2023-11-01)

Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
by: Jian Zhang, et al.
Published: (2022-10-01)

Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients
by: Yang Zheng, et al.
Published: (2022-04-01)

Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
by: Junyu Huo, et al.
Published: (2021-09-01)

Development of a prognostic gene signature for hepatocellular carcinoma
by: Cuiyun Wu, et al.
Published: (2022-01-01)