Insertion Depth Modulates Protein Kinase C-δ-C1b Domain Interactions with Membrane Cholesterol as Revealed by MD Simulations

Insertion Depth Modulates Protein Kinase C-δ-C1b Domain Interactions with Membrane Cholesterol as Revealed by MD Simulations

Protein kinase C delta (PKC-δ) is an important signaling molecule in human cells that has both proapoptotic as well as antiapoptotic functions. These conflicting activities can be modulated by two classes of ligands, phorbol esters and bryostatins. Phorbol esters are known tumor promoters, while bry...

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Bibliographic Details
Main Authors: Patrick T. Judge, Sarah A. Overall, Alexander B. Barnes
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
protein kinase C
cholesterol
bryostatin
phorbol esters
molecular dynamics
membrane bilayer
Online Access:https://www.mdpi.com/1422-0067/24/5/4598

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