Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
Abstract Background Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of da...
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| 格式: | 文件 |
| 语言: | English |
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BMC
2019-08-01
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| 丛编: | The Journal of Headache and Pain |
| 主题: | |
| 在线阅读: | http://link.springer.com/article/10.1186/s10194-019-1043-7 |
| _version_ | 1828399427922952192 |
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| author | Andrea M. Harriott Lauren C. Strother Marta Vila-Pueyo Philip R. Holland |
| author_facet | Andrea M. Harriott Lauren C. Strother Marta Vila-Pueyo Philip R. Holland |
| author_sort | Andrea M. Harriott |
| collection | DOAJ |
| description | Abstract Background Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders. |
| first_indexed | 2024-12-10T09:17:05Z |
| format | Article |
| id | doaj.art-70f070e3fe2941aab72da6e8a7a174c2 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-10T09:17:05Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-70f070e3fe2941aab72da6e8a7a174c22022-12-22T01:54:49ZengBMCThe Journal of Headache and Pain1129-23691129-23772019-08-0120111510.1186/s10194-019-1043-7Animal models of migraine and experimental techniques used to examine trigeminal sensory processingAndrea M. Harriott0Lauren C. Strother1Marta Vila-Pueyo2Philip R. Holland3Neurovascular Research Lab, Department of Radiology, Massachusetts General HospitalHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King’s College LondonHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King’s College LondonHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King’s College LondonAbstract Background Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.http://link.springer.com/article/10.1186/s10194-019-1043-7PainMigraineHeadachePreclinicalAnimal modelsElectrophysiology |
| spellingShingle | Andrea M. Harriott Lauren C. Strother Marta Vila-Pueyo Philip R. Holland Animal models of migraine and experimental techniques used to examine trigeminal sensory processing The Journal of Headache and Pain Pain Migraine Headache Preclinical Animal models Electrophysiology |
| title | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| title_full | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| title_fullStr | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| title_full_unstemmed | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| title_short | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| title_sort | animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
| topic | Pain Migraine Headache Preclinical Animal models Electrophysiology |
| url | http://link.springer.com/article/10.1186/s10194-019-1043-7 |
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