Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of prec...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22311-z |
| _version_ | 1818749660817260544 |
|---|---|
| author | Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang |
| author_facet | Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang |
| author_sort | Baharak Bahmani |
| collection | DOAJ |
| description | The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of preclinical solid tumors. |
| first_indexed | 2024-12-18T04:07:19Z |
| format | Article |
| id | doaj.art-70f51776b4444f01b293b1d2b1518bff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:07:19Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-70f51776b4444f01b293b1d2b1518bff2022-12-21T21:21:34ZengNature PortfolioNature Communications2041-17232021-03-0112111210.1038/s41467-021-22311-zIntratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumorsBaharak Bahmani0Hua Gong1Brian T. Luk2Kristofer J. Haushalter3Ethel DeTeresa4Mark Previti5Jiarong Zhou6Weiwei Gao7Jack D. Bui8Liangfang Zhang9Ronnie H. Fang10Jie Zhang11Cello Therapeutics, Inc.Department of NanoEngineering, University of California San DiegoCello Therapeutics, Inc.Cello Therapeutics, Inc.Cello Therapeutics, Inc.Cello Therapeutics, Inc.Department of NanoEngineering, University of California San DiegoDepartment of NanoEngineering, University of California San DiegoDepartment of Pathology, University of California San DiegoDepartment of NanoEngineering, University of California San DiegoDepartment of NanoEngineering, University of California San DiegoCello Therapeutics, Inc.The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of preclinical solid tumors.https://doi.org/10.1038/s41467-021-22311-z |
| spellingShingle | Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors Nature Communications |
| title | Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors |
| title_full | Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors |
| title_fullStr | Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors |
| title_full_unstemmed | Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors |
| title_short | Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors |
| title_sort | intratumoral immunotherapy using platelet cloaked nanoparticles enhances antitumor immunity in solid tumors |
| url | https://doi.org/10.1038/s41467-021-22311-z |
| work_keys_str_mv | AT baharakbahmani intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT huagong intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT briantluk intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT kristoferjhaushalter intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT etheldeteresa intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT markpreviti intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jiarongzhou intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT weiweigao intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jackdbui intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT liangfangzhang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT ronniehfang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jiezhang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors |