Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease ....
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19737-2 |
| _version_ | 1818841318555648000 |
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| author | Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager |
| author_facet | Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager |
| author_sort | Marta Olah |
| collection | DOAJ |
| description | Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease . |
| first_indexed | 2024-12-19T04:24:11Z |
| format | Article |
| id | doaj.art-70f5aedb5f20425e97be8410947e4a81 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:24:11Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-70f5aedb5f20425e97be8410947e4a812022-12-21T20:36:04ZengNature PortfolioNature Communications2041-17232020-11-0111111810.1038/s41467-020-19737-2Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s diseaseMarta Olah0Vilas Menon1Naomi Habib2Mariko F. Taga3Yiyi Ma4Christina J. Yung5Maria Cimpean6Anthony Khairallah7Guillermo Coronas-Samano8Roman Sankowski9Dominic Grün10Alexandra A. Kroshilina11Danielle Dionne12Rani A. Sarkis13Garth R. Cosgrove14Jeffrey Helgager15Jeffrey A. Golden16Page B. Pennell17Marco Prinz18Jean Paul G. Vonsattel19Andrew F. Teich20Julie A. Schneider21David A. Bennett22Aviv Regev23Wassim Elyaman24Elizabeth M. Bradshaw25Philip L. De Jager26Center for Translational and Computational Neuroimmunology, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCell Circuits Program, Broad InstituteCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterTaub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical CenterInstitute of Neuropathology, Medical Faculty, University of FreiburgMax-Planck-Institute of Immunobiology and EpigeneticsCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterCell Circuits Program, Broad InstituteDepartment of Neurology, Brigham and Women’s HospitalDepartment of Neurosurgery, Brigham and Women’s HospitalDepartment of Pathology, Brigham and Women’s HospitalDepartment of Pathology, Brigham and Women’s HospitalDepartment of Neurology, Brigham and Women’s HospitalInstitute of Neuropathology, Medical Faculty, University of FreiburgTaub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical CenterTaub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical CenterRush Alzheimer’s Disease Center, Rush University Medical CenterRush Alzheimer’s Disease Center, Rush University Medical CenterCell Circuits Program, Broad InstituteTaub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical CenterTaub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical CenterCenter for Translational and Computational Neuroimmunology, Columbia University Medical CenterImbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease .https://doi.org/10.1038/s41467-020-19737-2 |
| spellingShingle | Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease Nature Communications |
| title | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease |
| title_full | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease |
| title_fullStr | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease |
| title_full_unstemmed | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease |
| title_short | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease |
| title_sort | single cell rna sequencing of human microglia uncovers a subset associated with alzheimer s disease |
| url | https://doi.org/10.1038/s41467-020-19737-2 |
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