Rhabdomyolysis and autoimmune variant stiff-person syndrome
Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge n...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-11-01
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| Series: | Clinics and Practice |
| Subjects: | |
| Online Access: | https://www.clinicsandpractice.org/index.php/cp/article/view/885 |
| _version_ | 1818472973788512256 |
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| author | Shreyas Gangadhara Suhas Gangadhara Chetan Gandhy Derrick Robertson |
| author_facet | Shreyas Gangadhara Suhas Gangadhara Chetan Gandhy Derrick Robertson |
| author_sort | Shreyas Gangadhara |
| collection | DOAJ |
| description | Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge no case has been reported involving the autoimmune variant. We report a case report of a 50-year-old man with history of SPS who presented with recurrent episodes of severe limb and back spasms. He was hospitalized on two separate occasions for uncontrollable spasms associated with renal failure and creatinine phosphokinase elevations of 55,000 and 22,000 U/L respectively. Laboratory tests were otherwise unremarkable. The acute renal failure resolved during both admissions with supportive management. Rhabdomyolysis has the potential to be fatal and early diagnosis is essential. It should be considered in patients who have SPS and are experiencing an exacerbation of their neurologic condition. |
| first_indexed | 2024-04-14T04:16:21Z |
| format | Article |
| id | doaj.art-70f68a372df74e4486f9a1f524cecefc |
| institution | Directory Open Access Journal |
| issn | 2039-7275 2039-7283 |
| language | English |
| last_indexed | 2024-04-14T04:16:21Z |
| publishDate | 2016-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-70f68a372df74e4486f9a1f524cecefc2022-12-22T02:12:50ZengMDPI AGClinics and Practice2039-72752039-72832016-11-016410.4081/cp.2016.885364Rhabdomyolysis and autoimmune variant stiff-person syndromeShreyas Gangadhara0Suhas Gangadhara1Chetan Gandhy2Derrick Robertson3Division of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FL; Department of Neurology, James A Haley Veterans Hospital, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLStiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge no case has been reported involving the autoimmune variant. We report a case report of a 50-year-old man with history of SPS who presented with recurrent episodes of severe limb and back spasms. He was hospitalized on two separate occasions for uncontrollable spasms associated with renal failure and creatinine phosphokinase elevations of 55,000 and 22,000 U/L respectively. Laboratory tests were otherwise unremarkable. The acute renal failure resolved during both admissions with supportive management. Rhabdomyolysis has the potential to be fatal and early diagnosis is essential. It should be considered in patients who have SPS and are experiencing an exacerbation of their neurologic condition.https://www.clinicsandpractice.org/index.php/cp/article/view/885Stiff-person syndromerhabdomyolysisspasms. |
| spellingShingle | Shreyas Gangadhara Suhas Gangadhara Chetan Gandhy Derrick Robertson Rhabdomyolysis and autoimmune variant stiff-person syndrome Clinics and Practice Stiff-person syndrome rhabdomyolysis spasms. |
| title | Rhabdomyolysis and autoimmune variant stiff-person syndrome |
| title_full | Rhabdomyolysis and autoimmune variant stiff-person syndrome |
| title_fullStr | Rhabdomyolysis and autoimmune variant stiff-person syndrome |
| title_full_unstemmed | Rhabdomyolysis and autoimmune variant stiff-person syndrome |
| title_short | Rhabdomyolysis and autoimmune variant stiff-person syndrome |
| title_sort | rhabdomyolysis and autoimmune variant stiff person syndrome |
| topic | Stiff-person syndrome rhabdomyolysis spasms. |
| url | https://www.clinicsandpractice.org/index.php/cp/article/view/885 |
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