Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout
Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1240 |
| _version_ | 1826556841484615680 |
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| author | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva |
| author_facet | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva |
| author_sort | M. A. Gromova |
| collection | DOAJ |
| description | Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies. |
| first_indexed | 2024-04-10T02:05:23Z |
| format | Article |
| id | doaj.art-70f7b425888f4cb39f20cd98e9515f78 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2025-03-14T08:19:07Z |
| publishDate | 2021-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-70f7b425888f4cb39f20cd98e9515f782025-03-02T13:11:06ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-12-0115612412910.14412/1996-7012-2021-6-124-1292437Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and goutM. A. Gromova0V. V. Tsurko1O. A. Kislyak2E. V. Kiseleva3Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University; I.M. Sechenov First Moscow State Medical UniversityPirogov Russian National Research Medical UniversityN.N. Semenov Federal Research Center for chemical physicsFatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies.https://mrj.ima-press.net/mrj/article/view/1240fatty acidsmicrobiotainflammationmetabolic disordersatherosclerosisgout |
| spellingShingle | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout Современная ревматология fatty acids microbiota inflammation metabolic disorders atherosclerosis gout |
| title | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_full | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_fullStr | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_full_unstemmed | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_short | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_sort | role of fatty acids in inflammation atherosclerosis metabolic disorders and gout |
| topic | fatty acids microbiota inflammation metabolic disorders atherosclerosis gout |
| url | https://mrj.ima-press.net/mrj/article/view/1240 |
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