Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout
Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1240 |
| _version_ | 1797876673467645952 |
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| author | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva |
| author_facet | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva |
| author_sort | M. A. Gromova |
| collection | DOAJ |
| description | Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies. |
| first_indexed | 2024-04-10T02:05:23Z |
| format | Article |
| id | doaj.art-70f7b425888f4cb39f20cd98e9515f78 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:05:23Z |
| publishDate | 2021-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-70f7b425888f4cb39f20cd98e9515f782023-03-13T08:39:29ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-12-0115612412910.14412/1996-7012-2021-6-124-1292437Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and goutM. A. Gromova0V. V. Tsurko1O. A. Kislyak2E. V. Kiseleva3ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииФГБУН «Федеральный исследовательский центр химической физики им. Н.Н. Семенова» Российской академии наукFatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies.https://mrj.ima-press.net/mrj/article/view/1240жирные кислотымикробиотавоспалениеметаболические нарушенияатеросклерозподагра |
| spellingShingle | M. A. Gromova V. V. Tsurko O. A. Kislyak E. V. Kiseleva Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout Современная ревматология жирные кислоты микробиота воспаление метаболические нарушения атеросклероз подагра |
| title | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_full | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_fullStr | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_full_unstemmed | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_short | Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout |
| title_sort | role of fatty acids in inflammation atherosclerosis metabolic disorders and gout |
| topic | жирные кислоты микробиота воспаление метаболические нарушения атеросклероз подагра |
| url | https://mrj.ima-press.net/mrj/article/view/1240 |
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