Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype

Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype

Nerve growth factor (NGF) is critical for neuronal physiology during development and adulthood. Despite the well-recognized effect of NGF on neurons, less is known about whether NGF can actually affect other cell types in the central nervous system (CNS). In this work, we show that astrocytes are su...

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Bibliographic Details
Main Authors: Alexia Tiberi, Nicola Maria Carucci, Giovanna Testa, Caterina Rizzi, Paola Pacifico, Giulia Borgonovo, Ivan Arisi, Mara D’Onofrio, Rossella Brandi, Wen-Biao Gan, Simona Capsoni, Antonino Cattaneo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
astrocytes
NGF
calcium
co-cultures
reactive astrocytes
neurotrophins
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1165125/full

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