Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics
Rania M Fahmy,1,2 Ramesa S Bhat,3 Manar Al-Mutairi,4 Feda S Aljaser,5 Afaf El-Ansary4 1Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Giza, Egypt; 3Biochemistry Department...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/correlation-between-glycemic-control-and-peripapillary-retinal-nerve-f-peer-reviewed-article-OPTH |
| _version_ | 1818693700333600768 |
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| author | Fahmy RM Bhat RS Al-Mutairi M Aljaser FS El-Ansary A |
| author_facet | Fahmy RM Bhat RS Al-Mutairi M Aljaser FS El-Ansary A |
| author_sort | Fahmy RM |
| collection | DOAJ |
| description | Rania M Fahmy,1,2 Ramesa S Bhat,3 Manar Al-Mutairi,4 Feda S Aljaser,5 Afaf El-Ansary4 1Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Giza, Egypt; 3Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, Riyadh, Saudi Arabia; 5Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Objective: To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.Methods: The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c <7% and Subgroup 2: with HbA1c ≥7%. All patients underwent full ophthalmic examination. HbA1c level was obtained with the A1cNow+ system and the peripapillary RNFLT was measured using 3D-OCT 2000 Topcon (360-degree circular scan with 3.4 mm diameter centered on optic disc).Results: The obtained data demonstrates significant decrease in peripapillary RNFLT in superior and inferior quadrants of the right eye (p=0.000 and p=0.039, respectively), and in superior quadrant of the left eye (p=0.002) with impairment of glycemic control. Pearson’s correlation test showed significant negative correlation of RNFLT with HbA1c in the superior quadrant in both eyes.Conclusion: Impairment of glycemic control affects the peripapillary RNFLT mainly in the superior quadrant. This thickness also tends to decrease with long-standing DM, use of DM medications, and development of diabetic retinopathy. The measurement of peripapillary RNFLT may become a useful method to monitor early retinal changes in diabetic patients. Keywords: retina, RNFL, optical coherence tomography, diabetic retinopathy, glycosylated hemoglobin |
| first_indexed | 2024-12-17T13:17:51Z |
| format | Article |
| id | doaj.art-7101485c3bd747b08ba6a71cb2b70de7 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-17T13:17:51Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-7101485c3bd747b08ba6a71cb2b70de72022-12-21T21:46:57ZengDove Medical PressClinical Ophthalmology1177-54832018-03-01Volume 1241942537024Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabeticsFahmy RMBhat RSAl-Mutairi MAljaser FSEl-Ansary ARania M Fahmy,1,2 Ramesa S Bhat,3 Manar Al-Mutairi,4 Feda S Aljaser,5 Afaf El-Ansary4 1Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Giza, Egypt; 3Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 4Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, Riyadh, Saudi Arabia; 5Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Objective: To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.Methods: The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c <7% and Subgroup 2: with HbA1c ≥7%. All patients underwent full ophthalmic examination. HbA1c level was obtained with the A1cNow+ system and the peripapillary RNFLT was measured using 3D-OCT 2000 Topcon (360-degree circular scan with 3.4 mm diameter centered on optic disc).Results: The obtained data demonstrates significant decrease in peripapillary RNFLT in superior and inferior quadrants of the right eye (p=0.000 and p=0.039, respectively), and in superior quadrant of the left eye (p=0.002) with impairment of glycemic control. Pearson’s correlation test showed significant negative correlation of RNFLT with HbA1c in the superior quadrant in both eyes.Conclusion: Impairment of glycemic control affects the peripapillary RNFLT mainly in the superior quadrant. This thickness also tends to decrease with long-standing DM, use of DM medications, and development of diabetic retinopathy. The measurement of peripapillary RNFLT may become a useful method to monitor early retinal changes in diabetic patients. Keywords: retina, RNFL, optical coherence tomography, diabetic retinopathy, glycosylated hemoglobinhttps://www.dovepress.com/correlation-between-glycemic-control-and-peripapillary-retinal-nerve-f-peer-reviewed-article-OPTHRetinaRNFLoptical coherence tomographydiabetic retinopathyglycosylated hemoglobin |
| spellingShingle | Fahmy RM Bhat RS Al-Mutairi M Aljaser FS El-Ansary A Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics Clinical Ophthalmology Retina RNFL optical coherence tomography diabetic retinopathy glycosylated hemoglobin |
| title | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| title_full | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| title_fullStr | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| title_full_unstemmed | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| title_short | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| title_sort | correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in saudi type ii diabetics |
| topic | Retina RNFL optical coherence tomography diabetic retinopathy glycosylated hemoglobin |
| url | https://www.dovepress.com/correlation-between-glycemic-control-and-peripapillary-retinal-nerve-f-peer-reviewed-article-OPTH |
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