Essential Role of Rho-Associated Kinase in ABO Immune Complex-Mediated Endothelial Barrier Disruption

Essential Role of Rho-Associated Kinase in ABO Immune Complex-Mediated Endothelial Barrier Disruption

ABO immune complexes (ABO-IC) formed by ABO-incompatible antigen-antibody interaction are associated with hemolysis and platelet destruction in patients transfused with ABO-nonidentical blood products. However, the effects of ABO-IC on endothelial cells (EC) are unclear. ABO-IC were formed in vitro...

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Bibliographic Details
Main Authors: Hannah L. McRae, Michelle Warren Millar, Spencer A. Slavin, Neil Blumberg, Arshad Rahman, Majed A. Refaai
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
transfusion
endothelial cells
vascular biology
ABO blood groups
immune complexes
Online Access:https://www.mdpi.com/2227-9059/9/12/1851

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