Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds
<i>Mycoplasma bovis</i> is an important pathogen causing mostly pneumonia in calves and mastitis in dairy cattle. In the absence of an effective vaccine, antimicrobial therapy remains the main control measure. Antimicrobial use in veal calves is substantially higher than in conventional...
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MDPI AG
2020-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/12/882 |
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| author | Jade Bokma Linde Gille Koen De Bleecker Jozefien Callens Freddy Haesebrouck Bart Pardon Filip Boyen |
| author_facet | Jade Bokma Linde Gille Koen De Bleecker Jozefien Callens Freddy Haesebrouck Bart Pardon Filip Boyen |
| author_sort | Jade Bokma |
| collection | DOAJ |
| description | <i>Mycoplasma bovis</i> is an important pathogen causing mostly pneumonia in calves and mastitis in dairy cattle. In the absence of an effective vaccine, antimicrobial therapy remains the main control measure. Antimicrobial use in veal calves is substantially higher than in conventional herds, but whether veal calves also harbor more resistant <i>M. bovis</i> strains is currently unknown. Therefore, we compared antimicrobial susceptibility test results of <i>M. bovis</i> isolates from different cattle sectors and genomic clusters. The minimum inhibitory concentration of nine antimicrobials was determined for 141 Belgian <i>M. bovis</i> isolates (29 dairy, 69 beef, 12 mixed, 31 veal farms), and was used to estimate the epidemiological cut-off. Acquired resistance was frequently observed for the macrolides, while no acquired resistance to oxytetracycline and doxycycline, minimal acquired resistance to florfenicol and tiamulin, and a limited acquired resistance to enrofloxacin was seen. <i>M. bovis</i> isolates from beef cattle or genomic cluster III had higher odds of being gamithromycin-resistant than those from dairy cattle or genomic clusters IV and V. In this study, no cattle industry could be identified as source of resistant <i>M. bovis</i> strains. A single guideline for antimicrobial use for <i>M. bovis</i> infections, with a small remark for gamithromycin, is likely sufficient. |
| first_indexed | 2024-03-10T14:13:42Z |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T14:13:42Z |
| publishDate | 2020-12-01 |
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| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-71041642de4541bf99409b8eeec0d3752023-11-21T00:00:06ZengMDPI AGAntibiotics2079-63822020-12-0191288210.3390/antibiotics9120882Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef HerdsJade Bokma0Linde Gille1Koen De Bleecker2Jozefien Callens3Freddy Haesebrouck4Bart Pardon5Filip Boyen6Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumAnimal Health Service-Flanders, Industrielaan 29, 8820 Torhout, BelgiumAnimal Health Service-Flanders, Industrielaan 29, 8820 Torhout, BelgiumDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium<i>Mycoplasma bovis</i> is an important pathogen causing mostly pneumonia in calves and mastitis in dairy cattle. In the absence of an effective vaccine, antimicrobial therapy remains the main control measure. Antimicrobial use in veal calves is substantially higher than in conventional herds, but whether veal calves also harbor more resistant <i>M. bovis</i> strains is currently unknown. Therefore, we compared antimicrobial susceptibility test results of <i>M. bovis</i> isolates from different cattle sectors and genomic clusters. The minimum inhibitory concentration of nine antimicrobials was determined for 141 Belgian <i>M. bovis</i> isolates (29 dairy, 69 beef, 12 mixed, 31 veal farms), and was used to estimate the epidemiological cut-off. Acquired resistance was frequently observed for the macrolides, while no acquired resistance to oxytetracycline and doxycycline, minimal acquired resistance to florfenicol and tiamulin, and a limited acquired resistance to enrofloxacin was seen. <i>M. bovis</i> isolates from beef cattle or genomic cluster III had higher odds of being gamithromycin-resistant than those from dairy cattle or genomic clusters IV and V. In this study, no cattle industry could be identified as source of resistant <i>M. bovis</i> strains. A single guideline for antimicrobial use for <i>M. bovis</i> infections, with a small remark for gamithromycin, is likely sufficient.https://www.mdpi.com/2079-6382/9/12/882epidemiological cut-off methodsgamithromycingenomic clustersiterative statistical methodnormalized resistance interpretationvisual estimation |
| spellingShingle | Jade Bokma Linde Gille Koen De Bleecker Jozefien Callens Freddy Haesebrouck Bart Pardon Filip Boyen Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds Antibiotics epidemiological cut-off methods gamithromycin genomic clusters iterative statistical method normalized resistance interpretation visual estimation |
| title | Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds |
| title_full | Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds |
| title_fullStr | Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds |
| title_full_unstemmed | Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds |
| title_short | Antimicrobial Susceptibility of <i>Mycoplasma bovis</i> Isolates from Veal, Dairy and Beef Herds |
| title_sort | antimicrobial susceptibility of i mycoplasma bovis i isolates from veal dairy and beef herds |
| topic | epidemiological cut-off methods gamithromycin genomic clusters iterative statistical method normalized resistance interpretation visual estimation |
| url | https://www.mdpi.com/2079-6382/9/12/882 |
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