Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks
Background and objective: We recently reported improvements of working memory across 10 years post stroke among middle-aged individuals. However, the mechanisms underlying working-memory recovery are largely unknown. This study investigated the associations between long-term improvement of working m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000451 |
| _version_ | 1797869755936276480 |
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| author | Johan Eriksson Lars Nyberg Eva Elgh Xiaolei Hu |
| author_facet | Johan Eriksson Lars Nyberg Eva Elgh Xiaolei Hu |
| author_sort | Johan Eriksson |
| collection | DOAJ |
| description | Background and objective: We recently reported improvements of working memory across 10 years post stroke among middle-aged individuals. However, the mechanisms underlying working-memory recovery are largely unknown. This study investigated the associations between long-term improvement of working memory and resting-state functional connectivity in two frontoparietal networks: the frontoparietal network and the dorsal attention network. Methods: Working memory was repeatedly assessed by the Digit Span Backwards task in 21 persons, within 1 year after stroke onset and again 10 years post stroke onset. Brain functional connectivity was examined by resting state functional magnetic resonance imaging at the 10-year follow-up. Results: A significant improvement of working memory was found among 21 persons after stroke (median age = 64) at the 10-year follow-up compared to the within-one-year assessment. The magnitude of performance improvement on the Digit Span Backwards task was significantly positively correlated with stronger brain connectivity in the frontoparietal network (r = 0.51, p = 0.018) measured at the 10-year follow-up only. A similar association was observed in the dorsal attention network (r = 0.43, p = 0.052) but not in a visual network (r = -0.17, p = 0.46) that served as a control network. The association between functional connectivity within the above-mentioned networks and Digit Span Backwards scores at 10-year after stroke was in the same direction but did not reach significance. Conclusions: The present work relate stronger long-term performance improvement on the Digit Span Backwards task with higher integrity of frontoparietal network connectivity. |
| first_indexed | 2024-04-10T00:17:21Z |
| format | Article |
| id | doaj.art-71068e83ada34cb8a700cd2d25c2dfa6 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-10T00:17:21Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-71068e83ada34cb8a700cd2d25c2dfa62023-03-16T05:04:14ZengElsevierNeuroImage: Clinical2213-15822023-01-0137103356Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networksJohan Eriksson0Lars Nyberg1Eva Elgh2Xiaolei Hu3Umeå center for Functional Brain Imaging (UFBI) and Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, SwedenUmeå center for Functional Brain Imaging (UFBI) and Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden; Department of Radiation Sciences, Umeå University, 901 87 Umeå, SwedenDepartment of Psychology, Umeå University, 901 87 Umeå, SwedenDepartment of Community Medicine and Rehabilitation, Umeå University, 901 87 Umeå, Sweden; Corresponding author.Background and objective: We recently reported improvements of working memory across 10 years post stroke among middle-aged individuals. However, the mechanisms underlying working-memory recovery are largely unknown. This study investigated the associations between long-term improvement of working memory and resting-state functional connectivity in two frontoparietal networks: the frontoparietal network and the dorsal attention network. Methods: Working memory was repeatedly assessed by the Digit Span Backwards task in 21 persons, within 1 year after stroke onset and again 10 years post stroke onset. Brain functional connectivity was examined by resting state functional magnetic resonance imaging at the 10-year follow-up. Results: A significant improvement of working memory was found among 21 persons after stroke (median age = 64) at the 10-year follow-up compared to the within-one-year assessment. The magnitude of performance improvement on the Digit Span Backwards task was significantly positively correlated with stronger brain connectivity in the frontoparietal network (r = 0.51, p = 0.018) measured at the 10-year follow-up only. A similar association was observed in the dorsal attention network (r = 0.43, p = 0.052) but not in a visual network (r = -0.17, p = 0.46) that served as a control network. The association between functional connectivity within the above-mentioned networks and Digit Span Backwards scores at 10-year after stroke was in the same direction but did not reach significance. Conclusions: The present work relate stronger long-term performance improvement on the Digit Span Backwards task with higher integrity of frontoparietal network connectivity.http://www.sciencedirect.com/science/article/pii/S2213158223000451Functional connectivityWorking memoryCognitive improvementStrokeLong-term |
| spellingShingle | Johan Eriksson Lars Nyberg Eva Elgh Xiaolei Hu Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks NeuroImage: Clinical Functional connectivity Working memory Cognitive improvement Stroke Long-term |
| title | Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| title_full | Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| title_fullStr | Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| title_full_unstemmed | Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| title_short | Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| title_sort | improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks |
| topic | Functional connectivity Working memory Cognitive improvement Stroke Long-term |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000451 |
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