Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy
Abstract Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade for predicting recurrence, especially early recurrence, and overall survival in patients with...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-54260-0 |
| _version_ | 1827327967450103808 |
|---|---|
| author | Hengkai Chen Honghao Ye Linfang Ye Fangzhou Lin Yingjun Shi Aoxue Zhong Guoxian Guan Jinfu Zhuang |
| author_facet | Hengkai Chen Honghao Ye Linfang Ye Fangzhou Lin Yingjun Shi Aoxue Zhong Guoxian Guan Jinfu Zhuang |
| author_sort | Hengkai Chen |
| collection | DOAJ |
| description | Abstract Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade for predicting recurrence, especially early recurrence, and overall survival in patients with early-stage HCC after curative resection. We retrospectively reviewed the data of patients with early-stage HCC who underwent curative hepatectomy in the First Affiliated Hospital of Fujian Medical University (FHFU) and Mengchao Hepatobiliary Hospital of Fujian Medical University (MHH). Kaplan–Meier curves and Cox proportional hazards regression models were used to analyse disease-free survival (DFS) and overall survival (OS). Nomogram models were constructed on the datasets from the 70% samples of and FHFU, which were validated using bootstrap resampling with 30% samples as internal validation and data of patients from MHH as external validation. A total of 703 patients with early-stage HCC were included to create a nomogram for predicting recurrence or metastasis (DFS nomogram) and a nomogram for predicting survival (OS nomogram). The concordance indexes and calibration curves in the training and validation cohorts showed optimal agreement between the predicted and observed DFS and OS rates. The predictive accuracy was significantly better than that of the classic HCC staging systems. |
| first_indexed | 2024-03-07T15:10:08Z |
| format | Article |
| id | doaj.art-710903c526f04ce995671285a9b76f89 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:10:08Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-710903c526f04ce995671285a9b76f892024-03-05T18:42:12ZengNature PortfolioScientific Reports2045-23222024-02-0114111110.1038/s41598-024-54260-0Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomyHengkai Chen0Honghao Ye1Linfang Ye2Fangzhou Lin3Yingjun Shi4Aoxue Zhong5Guoxian Guan6Jinfu Zhuang7Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical UniversityFuzhou UniversityZhongshan Hospital Xiamen UniversityFuzhou UniversityFuzhou UniversityFuzhou UniversityDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical UniversityAbstract Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade for predicting recurrence, especially early recurrence, and overall survival in patients with early-stage HCC after curative resection. We retrospectively reviewed the data of patients with early-stage HCC who underwent curative hepatectomy in the First Affiliated Hospital of Fujian Medical University (FHFU) and Mengchao Hepatobiliary Hospital of Fujian Medical University (MHH). Kaplan–Meier curves and Cox proportional hazards regression models were used to analyse disease-free survival (DFS) and overall survival (OS). Nomogram models were constructed on the datasets from the 70% samples of and FHFU, which were validated using bootstrap resampling with 30% samples as internal validation and data of patients from MHH as external validation. A total of 703 patients with early-stage HCC were included to create a nomogram for predicting recurrence or metastasis (DFS nomogram) and a nomogram for predicting survival (OS nomogram). The concordance indexes and calibration curves in the training and validation cohorts showed optimal agreement between the predicted and observed DFS and OS rates. The predictive accuracy was significantly better than that of the classic HCC staging systems.https://doi.org/10.1038/s41598-024-54260-0NomogramMicrovascular invasion gradeEarly-stage HCCEarly recurrence |
| spellingShingle | Hengkai Chen Honghao Ye Linfang Ye Fangzhou Lin Yingjun Shi Aoxue Zhong Guoxian Guan Jinfu Zhuang Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy Scientific Reports Nomogram Microvascular invasion grade Early-stage HCC Early recurrence |
| title | Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy |
| title_full | Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy |
| title_fullStr | Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy |
| title_full_unstemmed | Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy |
| title_short | Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy |
| title_sort | novel nomograms based on microvascular invasion grade for early stage hepatocellular carcinoma after curative hepatectomy |
| topic | Nomogram Microvascular invasion grade Early-stage HCC Early recurrence |
| url | https://doi.org/10.1038/s41598-024-54260-0 |
| work_keys_str_mv | AT hengkaichen novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT honghaoye novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT linfangye novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT fangzhoulin novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT yingjunshi novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT aoxuezhong novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT guoxianguan novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy AT jinfuzhuang novelnomogramsbasedonmicrovascularinvasiongradeforearlystagehepatocellularcarcinomaaftercurativehepatectomy |