Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. Specifically, by using a virtual fragment screening approach of aromatic bromides, straightforward...

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Bibliographic Details
Main Authors:	Simone Di Micco, Stefania Terracciano, Dafne Ruggiero, Marianna Potenza, Maria C. Vaccaro, Katrin Fischer, Oliver Werz, Ines Bruno, Giuseppe Bifulco
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Chemistry
Subjects:	fragment-based approach Suzuki-Miyaura cross-coupling mPGES-1 inhibitors anti-inflammatory drugs anticancer agents
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2021.676631/full

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