Peptide Aggregation Induced Immunogenic Rupture (PAIIR)
Abstract Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage‐associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response. In the presence of an antigen, DAMPs ride the longevity and eff...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202105868 |
| _version_ | 1818043635499794432 |
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| author | Gokhan Gunay Seren Hamsici Gillian A. Lang Mark L. Lang Susan Kovats Handan Acar |
| author_facet | Gokhan Gunay Seren Hamsici Gillian A. Lang Mark L. Lang Susan Kovats Handan Acar |
| author_sort | Gokhan Gunay |
| collection | DOAJ |
| description | Abstract Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage‐associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response. In the presence of an antigen, DAMPs ride the longevity and efficacy of antigen‐specific immunity. Yet, no tool can induce the controlled ICD with predictable results. A peptide‐based tool, [II], is designed that aggregates in the cell and causes cell membrane damage, generates ICD and DAMPs release on various cell types, and hence can act as an adjuvant. An influenza vaccine is prepared by combining [II] with influenza hemagglutinin (HA) subunit antigens. The results show that [II] induced significantly higher HA‐specific immunoglobulin G1 (IgG1) and IgG2a antibodies than HA‐only immunized mice, while the peptide itself did not elicit antibodies. This paper demonstrates the first peptide‐aggregation induced immunogenic rupture (PAIIR) approach as a vaccine adjuvant. PAIIR is a promising adjuvant with a high potential to promote universal protection upon influenza HA vaccination. |
| first_indexed | 2024-12-10T09:05:21Z |
| format | Article |
| id | doaj.art-710afa6a8ad14dd3a044b7b07da8a021 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T09:05:21Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-710afa6a8ad14dd3a044b7b07da8a0212022-12-22T01:55:10ZengWileyAdvanced Science2198-38442022-07-01921n/an/a10.1002/advs.202105868Peptide Aggregation Induced Immunogenic Rupture (PAIIR)Gokhan Gunay0Seren Hamsici1Gillian A. Lang2Mark L. Lang3Susan Kovats4Handan Acar5Stephenson School of Biomedical Engineering University of Oklahoma Norman OK 73069 USAStephenson School of Biomedical Engineering University of Oklahoma Norman OK 73069 USADepartment of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USADepartment of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USADepartment of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USAStephenson School of Biomedical Engineering University of Oklahoma Norman OK 73069 USAAbstract Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage‐associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response. In the presence of an antigen, DAMPs ride the longevity and efficacy of antigen‐specific immunity. Yet, no tool can induce the controlled ICD with predictable results. A peptide‐based tool, [II], is designed that aggregates in the cell and causes cell membrane damage, generates ICD and DAMPs release on various cell types, and hence can act as an adjuvant. An influenza vaccine is prepared by combining [II] with influenza hemagglutinin (HA) subunit antigens. The results show that [II] induced significantly higher HA‐specific immunoglobulin G1 (IgG1) and IgG2a antibodies than HA‐only immunized mice, while the peptide itself did not elicit antibodies. This paper demonstrates the first peptide‐aggregation induced immunogenic rupture (PAIIR) approach as a vaccine adjuvant. PAIIR is a promising adjuvant with a high potential to promote universal protection upon influenza HA vaccination.https://doi.org/10.1002/advs.202105868damage‐associated molecular patternsimmunogenic cell deathinfluenza vaccinationpeptide aggregation |
| spellingShingle | Gokhan Gunay Seren Hamsici Gillian A. Lang Mark L. Lang Susan Kovats Handan Acar Peptide Aggregation Induced Immunogenic Rupture (PAIIR) Advanced Science damage‐associated molecular patterns immunogenic cell death influenza vaccination peptide aggregation |
| title | Peptide Aggregation Induced Immunogenic Rupture (PAIIR) |
| title_full | Peptide Aggregation Induced Immunogenic Rupture (PAIIR) |
| title_fullStr | Peptide Aggregation Induced Immunogenic Rupture (PAIIR) |
| title_full_unstemmed | Peptide Aggregation Induced Immunogenic Rupture (PAIIR) |
| title_short | Peptide Aggregation Induced Immunogenic Rupture (PAIIR) |
| title_sort | peptide aggregation induced immunogenic rupture paiir |
| topic | damage‐associated molecular patterns immunogenic cell death influenza vaccination peptide aggregation |
| url | https://doi.org/10.1002/advs.202105868 |
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