Dermatophyte infection: from fungal pathogenicity to host immune responses
Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of gre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1285887/full |
| _version_ | 1797640475757248512 |
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| author | Ruixin Deng Ruixin Deng Ruixin Deng Ruixin Deng Xiaowen Wang Xiaowen Wang Xiaowen Wang Xiaowen Wang Ruoyu Li Ruoyu Li Ruoyu Li Ruoyu Li |
| author_facet | Ruixin Deng Ruixin Deng Ruixin Deng Ruixin Deng Xiaowen Wang Xiaowen Wang Xiaowen Wang Xiaowen Wang Ruoyu Li Ruoyu Li Ruoyu Li Ruoyu Li |
| author_sort | Ruixin Deng |
| collection | DOAJ |
| description | Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of great help to understand the pathogenesis of dermatophytes, including fungal virulence factors and anti-pathogen immune responses. This review aims to summarize the recent advances in host-fungal interactions, focusing on the mechanisms of anti-fungal immunity and the relationship between immune deficiency and chronic dermatophytosis, in order to facilitate novel diagnostic and therapeutic approaches to improve the outcomes of these patients. |
| first_indexed | 2024-03-11T13:32:27Z |
| format | Article |
| id | doaj.art-710e565a154a431ba85b7086c9663b10 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T13:32:27Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-710e565a154a431ba85b7086c9663b102023-11-02T17:10:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12858871285887Dermatophyte infection: from fungal pathogenicity to host immune responsesRuixin Deng0Ruixin Deng1Ruixin Deng2Ruixin Deng3Xiaowen Wang4Xiaowen Wang5Xiaowen Wang6Xiaowen Wang7Ruoyu Li8Ruoyu Li9Ruoyu Li10Ruoyu Li11Department of Dermatology and Venerology, Peking University First Hospital, Beijing, ChinaResearch Center for Medical Mycology, Peking University, Beijing, ChinaNational Clinical Research Center for Skin and Immune Diseases, Beijing, ChinaBeijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, ChinaResearch Center for Medical Mycology, Peking University, Beijing, ChinaNational Clinical Research Center for Skin and Immune Diseases, Beijing, ChinaBeijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, ChinaResearch Center for Medical Mycology, Peking University, Beijing, ChinaNational Clinical Research Center for Skin and Immune Diseases, Beijing, ChinaBeijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaDermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of great help to understand the pathogenesis of dermatophytes, including fungal virulence factors and anti-pathogen immune responses. This review aims to summarize the recent advances in host-fungal interactions, focusing on the mechanisms of anti-fungal immunity and the relationship between immune deficiency and chronic dermatophytosis, in order to facilitate novel diagnostic and therapeutic approaches to improve the outcomes of these patients.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1285887/fulldermatophyteproteaseinnate immune responsepattern recognition receptorscaspase-associated recruitment domain 9type 1 immune response |
| spellingShingle | Ruixin Deng Ruixin Deng Ruixin Deng Ruixin Deng Xiaowen Wang Xiaowen Wang Xiaowen Wang Xiaowen Wang Ruoyu Li Ruoyu Li Ruoyu Li Ruoyu Li Dermatophyte infection: from fungal pathogenicity to host immune responses Frontiers in Immunology dermatophyte protease innate immune response pattern recognition receptors caspase-associated recruitment domain 9 type 1 immune response |
| title | Dermatophyte infection: from fungal pathogenicity to host immune responses |
| title_full | Dermatophyte infection: from fungal pathogenicity to host immune responses |
| title_fullStr | Dermatophyte infection: from fungal pathogenicity to host immune responses |
| title_full_unstemmed | Dermatophyte infection: from fungal pathogenicity to host immune responses |
| title_short | Dermatophyte infection: from fungal pathogenicity to host immune responses |
| title_sort | dermatophyte infection from fungal pathogenicity to host immune responses |
| topic | dermatophyte protease innate immune response pattern recognition receptors caspase-associated recruitment domain 9 type 1 immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1285887/full |
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