MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium

MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium

Oxidative damage is one of the major contributors to retinal degenerative diseases such as age-related macular degeneration (AMD), while RPE mediated antioxidant defense plays an important role in preventing retinopathies. However, the regulatory mechanisms of antioxidant signaling in RPE cells are...

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Bibliographic Details
Main Authors: Shuxian Han, Jianjun Chen, Jiajia Hua, Xiaojuan Hu, Shuhui Jian, Guoxiao Zheng, Jing Wang, Huirong Li, Jinglei Yang, J. Fielding Hejtmancik, Jia Qu, Xiaoyin Ma, Ling Hou
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Antioxidant
Retinal degeneration
NRF2
RPE
MITF
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302718

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