Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome
People living with HIV infection are at high risk for cardiovascular events due to inflammation and atherosclerosis. Also, some antiretroviral therapies may contribute to the risk of cardiovascular complications. Immune status is highly dependent on the level of lymphocyte T helper CD4+. There are d...
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MDPI AG
2023-08-01
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author | Mircea Bajdechi Adriana Gurghean Vlad Bataila Alexandru Scafa-Udriște Georgiana-Elena Bajdechi Roxana Radoi Anca Cristiana Oprea Valentin Chioncel Iuliana Mateescu Lucia Zekra Roxana Cernat Irina Magdalena Dumitru Sorin Rugina |
author_facet | Mircea Bajdechi Adriana Gurghean Vlad Bataila Alexandru Scafa-Udriște Georgiana-Elena Bajdechi Roxana Radoi Anca Cristiana Oprea Valentin Chioncel Iuliana Mateescu Lucia Zekra Roxana Cernat Irina Magdalena Dumitru Sorin Rugina |
author_sort | Mircea Bajdechi |
collection | DOAJ |
description | People living with HIV infection are at high risk for cardiovascular events due to inflammation and atherosclerosis. Also, some antiretroviral therapies may contribute to the risk of cardiovascular complications. Immune status is highly dependent on the level of lymphocyte T helper CD4+. There are data suggesting that immune status and CD4+ cell count may be involved in the development of cardiovascular complications in these patients. Our study is longitudinal and retrospective and included a total number of 50 patients with HIV infection associated with acute coronary syndrome, divided into two subgroups based on the nadir of CD4+ cells. This study analyzes the relationship between the immune status of HIV patients, assessed by the nadir of the CD4+ T-cell count, and the outcome of these patients. Also, secondary endpoints were the assessment of the magnitude of coronary lesions and of thrombotic and bleeding risk assessed by specific scores. Clinical and biological parameters and also the extension and complexity of coronary lesions were assessed. Although patients with poor immune status had more complex coronary lesions and increased operative risk and bleeding risk at one year, this was not associated with significant differences in major adverse cardiac and cerebrovascular events at the 30-day and 1-year outcomes. |
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format | Article |
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institution | Directory Open Access Journal |
issn | 2075-4418 |
language | English |
last_indexed | 2024-03-11T00:00:16Z |
publishDate | 2023-08-01 |
publisher | MDPI AG |
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series | Diagnostics |
spelling | doaj.art-710f3b54fac8442586fbd301ed2a3e192023-11-19T00:48:36ZengMDPI AGDiagnostics2075-44182023-08-011316268210.3390/diagnostics13162682Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary SyndromeMircea Bajdechi0Adriana Gurghean1Vlad Bataila2Alexandru Scafa-Udriște3Georgiana-Elena Bajdechi4Roxana Radoi5Anca Cristiana Oprea6Valentin Chioncel7Iuliana Mateescu8Lucia Zekra9Roxana Cernat10Irina Magdalena Dumitru11Sorin Rugina12Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaEmergency Clinical Hospital of Bucharest, 014461 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaClinical Hospital of Infectious and Tropical Disease “Dr. Victor Babes” of Bucharest, 030303 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila” of Bucharest, 050474 Bucharest, RomaniaDoctoral School of Medicine, “Ovidius” University of Constanta, 900470 Constanta, RomaniaDoctoral School of Medicine, “Ovidius” University of Constanta, 900470 Constanta, RomaniaDoctoral School of Medicine, “Ovidius” University of Constanta, 900470 Constanta, RomaniaDoctoral School of Medicine, “Ovidius” University of Constanta, 900470 Constanta, RomaniaPeople living with HIV infection are at high risk for cardiovascular events due to inflammation and atherosclerosis. Also, some antiretroviral therapies may contribute to the risk of cardiovascular complications. Immune status is highly dependent on the level of lymphocyte T helper CD4+. There are data suggesting that immune status and CD4+ cell count may be involved in the development of cardiovascular complications in these patients. Our study is longitudinal and retrospective and included a total number of 50 patients with HIV infection associated with acute coronary syndrome, divided into two subgroups based on the nadir of CD4+ cells. This study analyzes the relationship between the immune status of HIV patients, assessed by the nadir of the CD4+ T-cell count, and the outcome of these patients. Also, secondary endpoints were the assessment of the magnitude of coronary lesions and of thrombotic and bleeding risk assessed by specific scores. Clinical and biological parameters and also the extension and complexity of coronary lesions were assessed. Although patients with poor immune status had more complex coronary lesions and increased operative risk and bleeding risk at one year, this was not associated with significant differences in major adverse cardiac and cerebrovascular events at the 30-day and 1-year outcomes.https://www.mdpi.com/2075-4418/13/16/2682atherosclerosisacute coronary syndromeHIVchronic inflammationCD4+ lymphocytes |
spellingShingle | Mircea Bajdechi Adriana Gurghean Vlad Bataila Alexandru Scafa-Udriște Georgiana-Elena Bajdechi Roxana Radoi Anca Cristiana Oprea Valentin Chioncel Iuliana Mateescu Lucia Zekra Roxana Cernat Irina Magdalena Dumitru Sorin Rugina Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome Diagnostics atherosclerosis acute coronary syndrome HIV chronic inflammation CD4+ lymphocytes |
title | Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome |
title_full | Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome |
title_fullStr | Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome |
title_full_unstemmed | Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome |
title_short | Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome |
title_sort | particular aspects related to cd4 level in a group of hiv infected patients and associated acute coronary syndrome |
topic | atherosclerosis acute coronary syndrome HIV chronic inflammation CD4+ lymphocytes |
url | https://www.mdpi.com/2075-4418/13/16/2682 |
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