The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop exercise-induced ventricular tachyarrhythmias. In cardiomyocytes, increased mitochondrial matrix Ca2+...

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Bibliographic Details
Main Authors: Jörg W. Wegener, Ahmed Wagdi, Eva Wagner, Dörthe M. Katschinski, Gerd Hasenfuss, Tobias Bruegmann, Stephan E. Lehnart
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Physiology
Subjects:
ryanodine receptor
mitochondria
dantrolene
glutathione redox potential
RyR2 Ca2+ leak
mitochondrial oxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.777770/full

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