Fast calcium transients in dendritic spines driven by extreme statistics.
Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes. In dendritic s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-06-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.2006202 |
| _version_ | 1818238767790555136 |
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| author | Kanishka Basnayake David Mazaud Alexis Bemelmans Nathalie Rouach Eduard Korkotian David Holcman |
| author_facet | Kanishka Basnayake David Mazaud Alexis Bemelmans Nathalie Rouach Eduard Korkotian David Holcman |
| author_sort | Kanishka Basnayake |
| collection | DOAJ |
| description | Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes. In dendritic spines receiving synaptic inputs, we show here that in the presence of a spine apparatus (SA), which is an extension of the smooth ER, a calcium-induced calcium release (CICR) is triggered at the base of the spine by the fastest calcium ions arriving at a Ryanodyne receptor (RyR). The mechanism relies on the asymmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a computational model and further confirm experimentally in culture and slice hippocampal neurons. The present mechanism for which the statistics of the fastest particles arriving at a small target, followed by an amplification, is likely to be generic in molecular transduction across cellular microcompartments, such as thin neuronal processes, astrocytes, endfeets, or protrusions. |
| first_indexed | 2024-12-12T12:46:53Z |
| format | Article |
| id | doaj.art-7111061f3b914fb3b29676d4e72a118d |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-12T12:46:53Z |
| publishDate | 2019-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-7111061f3b914fb3b29676d4e72a118d2022-12-22T00:24:05ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852019-06-01176e200620210.1371/journal.pbio.2006202Fast calcium transients in dendritic spines driven by extreme statistics.Kanishka BasnayakeDavid MazaudAlexis BemelmansNathalie RouachEduard KorkotianDavid HolcmanFast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes. In dendritic spines receiving synaptic inputs, we show here that in the presence of a spine apparatus (SA), which is an extension of the smooth ER, a calcium-induced calcium release (CICR) is triggered at the base of the spine by the fastest calcium ions arriving at a Ryanodyne receptor (RyR). The mechanism relies on the asymmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a computational model and further confirm experimentally in culture and slice hippocampal neurons. The present mechanism for which the statistics of the fastest particles arriving at a small target, followed by an amplification, is likely to be generic in molecular transduction across cellular microcompartments, such as thin neuronal processes, astrocytes, endfeets, or protrusions.https://doi.org/10.1371/journal.pbio.2006202 |
| spellingShingle | Kanishka Basnayake David Mazaud Alexis Bemelmans Nathalie Rouach Eduard Korkotian David Holcman Fast calcium transients in dendritic spines driven by extreme statistics. PLoS Biology |
| title | Fast calcium transients in dendritic spines driven by extreme statistics. |
| title_full | Fast calcium transients in dendritic spines driven by extreme statistics. |
| title_fullStr | Fast calcium transients in dendritic spines driven by extreme statistics. |
| title_full_unstemmed | Fast calcium transients in dendritic spines driven by extreme statistics. |
| title_short | Fast calcium transients in dendritic spines driven by extreme statistics. |
| title_sort | fast calcium transients in dendritic spines driven by extreme statistics |
| url | https://doi.org/10.1371/journal.pbio.2006202 |
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