Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile

Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile

ABSTRACTCRISPR-Cas systems provide prokaryotic hosts with adaptive immunity against mobile genetic elements. Many bacteriophages encode anti-CRISPR (Acr) proteins that inhibit host defense. The identification of Acr proteins is challenging due to their small size and high sequence diversity, and onl...

Full description

Bibliographic Details
Main Authors: Polina Muzyukina, Anton Shkaruta, Noemi M. Guzman, Jessica Andreani, Adair L. Borges, Joseph Bondy-Denomy, Anna Maikova, Ekaterina Semenova, Konstantin Severinov, Olga Soutourina
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mSphere
Subjects:
Clostridioides difficile
type I-B CRISPR-Cas interference
cas operons
enteropathogen
anti-CRISPR
DNA mimicry
Online Access:https://journals.asm.org/doi/10.1128/msphere.00401-23

Similar Items

Similar Items