Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed bre...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-10-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2021-0113 |
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| author | Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques |
| author_facet | Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques |
| author_sort | Zouré Abdou Azaque |
| collection | DOAJ |
| description | Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information. |
| first_indexed | 2024-04-12T12:12:30Z |
| format | Article |
| id | doaj.art-7114d3260cc844129f4e9785dec6afb8 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-12T12:12:30Z |
| publishDate | 2021-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-7114d3260cc844129f4e9785dec6afb82022-12-22T03:33:33ZengDe GruyterOpen Life Sciences2391-54122021-10-011611101111010.1515/biol-2021-0113Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina FasoZouré Abdou Azaque0Amegnona Lanyo Jospin1Zongo Nayi2Kiendrebeogo Isabelle Touwendpoulimdé3Sorgho Pegdwendé Abel4Zongo Fabienne Ingrid5Yonli Albert Théophane6Sombié Herman Karim7Bambara Aboubacar Hierrhum8Sawadogo Alexis Yobi9Ouedraogo Marie N. L.10Traoré Lassina11Zongo Sidnooma Véronique12Lallogo Doriane Tatiana13Bazié Bapio Valery Jean Télesphore Elvira14Zohoncon Théodora M.15Dijgma Florencia W.16Simpore Jacques17Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartment of Surgery and Surgical Specialties, Service of General and Digestive Surgery, University Hospital Centre-Yalgado OUEDRAOGO, UFR/SDS, University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartment of Medicine and Medical Specialties, Service of Oncology, University Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, UFR/SDS, 03 BP 7021, Ouagadougou 03, Burkina Faso Department of Gynecology-Obstetrics, Service of Gynecology, University Hospital Centre-BOGODOGO, University Joseph KI ZERBO, UFR/SDS, 03 BP 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoDepartement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina FasoSeveral factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.https://doi.org/10.1515/biol-2021-0113breast cancerhla-drb1*11hla-drb1*12risk factorsburkina faso |
| spellingShingle | Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso Open Life Sciences breast cancer hla-drb1*11 hla-drb1*12 risk factors burkina faso |
| title | Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_full | Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_fullStr | Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_full_unstemmed | Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_short | Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_sort | carriage of hla drb1 11 and 1 12 alleles and risk factors in patients with breast cancer in burkina faso |
| topic | breast cancer hla-drb1*11 hla-drb1*12 risk factors burkina faso |
| url | https://doi.org/10.1515/biol-2021-0113 |
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