Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study
Primary hypothyroidism is associated with oxidative stress and insufficient antioxidant capacity. This study was conducted to evaluate the effects of levothyroxine replacement therapy on paraoxonase 1 (PON-1) serum levels in a patients with primary hypothyroidism. Thirty-one patients with primary hy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=3;spage=113;epage=118;aulast=Al-Naimi |
| _version_ | 1828867733663514624 |
|---|---|
| author | Marwa S Al-Naimi Nawar R Hussien Huda A Rasheed Hayder M Al-kuraishy Ali I Al-Gareeb |
| author_facet | Marwa S Al-Naimi Nawar R Hussien Huda A Rasheed Hayder M Al-kuraishy Ali I Al-Gareeb |
| author_sort | Marwa S Al-Naimi |
| collection | DOAJ |
| description | Primary hypothyroidism is associated with oxidative stress and insufficient antioxidant capacity. This study was conducted to evaluate the effects of levothyroxine replacement therapy on paraoxonase 1 (PON-1) serum levels in a patients with primary hypothyroidism. Thirty-one patients with primary hypothyroidism compared to 20 healthy controls were recruited from. A venous blood sample were taken after an overnight fasting for biochemical parameters, before and after starting levothyroxine therapy (100 μ g/day) for 3 months duration. The biochemical variables were PON-1 serum levels, lipid profiles, triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone (TSH) serum levels. Levothyroxine replacement therapy leads to a significant amelioration of thyroid functions, lipid profile, cardiometabolic measures P < 0.05 in patients with primary hypothyroidism. Levothyroxine leads to significant elevation in PON-1 serum levels from 188.42 ± 19.81 (U/mL) to 361.23 ± 33.62 (U/mL) P < 0.0001. This study concluded that levothyroxine replacement therapy significantly increases PON-1 serum levels in patients with primary hypothyroidism and attenuating hypothyroidism-induced oxidative stress. |
| first_indexed | 2024-12-13T05:16:50Z |
| format | Article |
| id | doaj.art-7114e81fd575414a9231c58aca414ca9 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-13T05:16:50Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-7114e81fd575414a9231c58aca414ca92022-12-21T23:58:24ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942018-01-019311311810.4103/japtr.JAPTR_298_18Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control studyMarwa S Al-NaimiNawar R HussienHuda A RasheedHayder M Al-kuraishyAli I Al-GareebPrimary hypothyroidism is associated with oxidative stress and insufficient antioxidant capacity. This study was conducted to evaluate the effects of levothyroxine replacement therapy on paraoxonase 1 (PON-1) serum levels in a patients with primary hypothyroidism. Thirty-one patients with primary hypothyroidism compared to 20 healthy controls were recruited from. A venous blood sample were taken after an overnight fasting for biochemical parameters, before and after starting levothyroxine therapy (100 μ g/day) for 3 months duration. The biochemical variables were PON-1 serum levels, lipid profiles, triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone (TSH) serum levels. Levothyroxine replacement therapy leads to a significant amelioration of thyroid functions, lipid profile, cardiometabolic measures P < 0.05 in patients with primary hypothyroidism. Levothyroxine leads to significant elevation in PON-1 serum levels from 188.42 ± 19.81 (U/mL) to 361.23 ± 33.62 (U/mL) P < 0.0001. This study concluded that levothyroxine replacement therapy significantly increases PON-1 serum levels in patients with primary hypothyroidism and attenuating hypothyroidism-induced oxidative stress.http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=3;spage=113;epage=118;aulast=Al-NaimiHypothyroidismlevothyroxinePON-1 |
| spellingShingle | Marwa S Al-Naimi Nawar R Hussien Huda A Rasheed Hayder M Al-kuraishy Ali I Al-Gareeb Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study Journal of Advanced Pharmaceutical Technology & Research Hypothyroidism levothyroxine PON-1 |
| title | Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study |
| title_full | Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study |
| title_fullStr | Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study |
| title_full_unstemmed | Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study |
| title_short | Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study |
| title_sort | levothyroxine improves paraoxonase pon 1 serum levels in patients with primary hypothyroidism case control study |
| topic | Hypothyroidism levothyroxine PON-1 |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=3;spage=113;epage=118;aulast=Al-Naimi |
| work_keys_str_mv | AT marwasalnaimi levothyroxineimprovesparaoxonasepon1serumlevelsinpatientswithprimaryhypothyroidismcasecontrolstudy AT nawarrhussien levothyroxineimprovesparaoxonasepon1serumlevelsinpatientswithprimaryhypothyroidismcasecontrolstudy AT hudaarasheed levothyroxineimprovesparaoxonasepon1serumlevelsinpatientswithprimaryhypothyroidismcasecontrolstudy AT haydermalkuraishy levothyroxineimprovesparaoxonasepon1serumlevelsinpatientswithprimaryhypothyroidismcasecontrolstudy AT aliialgareeb levothyroxineimprovesparaoxonasepon1serumlevelsinpatientswithprimaryhypothyroidismcasecontrolstudy |