Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae
Introduction: The Matricaria chamomilla plant is one of the most important plants used for the therapeutic purposes. More than 120 chemical constituents have been identified in Matricaria chamomile plant including 28 terpenoids and 36 flavonoids. This plant has a variety of therapeutic applications...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2013-04-01
|
| Series: | Journal of HerbMed Pharmacology |
| Subjects: | |
| Online Access: | http://www.herbmedpharmacol.com/PDF/JHP-2-49.pdf |
| _version_ | 1798016750700199936 |
|---|---|
| author | Hosseinpour Maryam Mobini-Dehkordi Mohsen Saffar Behnaz Teimori Hossein |
| author_facet | Hosseinpour Maryam Mobini-Dehkordi Mohsen Saffar Behnaz Teimori Hossein |
| author_sort | Hosseinpour Maryam |
| collection | DOAJ |
| description | Introduction: The Matricaria chamomilla plant is one of the most important plants used for the therapeutic purposes. More than 120 chemical constituents have been identified in Matricaria chamomile plant including 28 terpenoids and 36 flavonoids. This plant has a variety of therapeutic applications including the treatment of diabetes, eczema, wounds and gastrointestinal diseases. The Saccharomyces cerevisiae yeast is a non-pathogenic organism that is used as a model for pathogenic yeasts in order to identify compounds with antifungal properties and also to identify functional mechanism of these compounds. The aim of this study is to investigate the antifungal effect of Matricaria chamomilla hydroalcoholic extract on S. cerevisiae yeast. Methods: In this study Matricaria chamomilla extract was prepared by maceration method. In order to study the extract effect on growth and survival rate of the yeast cell, the spectrophotometry and methylene blue staining methods were used. Excel and SPSS 11 softwares were used to determine amounts and to infer the difference between control and treatment samples. Results: Results obtained from spectrophotometry and analyses of methylene blue staining showed that the Matricaria chamomilla extract at the concentration of 3000 μg/ml caused a significant decrease in the yeast growth and reduced the cells survival rate up to 48% (p< 0.05). Conclusion: Results of this research confirm that the hydroalcoholic extract of Matricaria chamomilla has antiproliferative effect on Saccharomyces cerevisiae. |
| first_indexed | 2024-04-11T15:55:45Z |
| format | Article |
| id | doaj.art-711514fffcba4728a0c399fab7038d0e |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T15:55:45Z |
| publishDate | 2013-04-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-711514fffcba4728a0c399fab7038d0e2022-12-22T04:15:10ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042013-04-01224951JHP_20150526224702Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiaeHosseinpour Maryam0Mobini-Dehkordi Mohsen1Saffar Behnaz2Teimori Hossein3Department of Genetics, Shahrekord University, Shahrekord, IranDepartment of Genetics, Shahrekord University, Shahrekord, IranDepartment of Genetics, Shahrekord University, Shahrekord, IranCellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranIntroduction: The Matricaria chamomilla plant is one of the most important plants used for the therapeutic purposes. More than 120 chemical constituents have been identified in Matricaria chamomile plant including 28 terpenoids and 36 flavonoids. This plant has a variety of therapeutic applications including the treatment of diabetes, eczema, wounds and gastrointestinal diseases. The Saccharomyces cerevisiae yeast is a non-pathogenic organism that is used as a model for pathogenic yeasts in order to identify compounds with antifungal properties and also to identify functional mechanism of these compounds. The aim of this study is to investigate the antifungal effect of Matricaria chamomilla hydroalcoholic extract on S. cerevisiae yeast. Methods: In this study Matricaria chamomilla extract was prepared by maceration method. In order to study the extract effect on growth and survival rate of the yeast cell, the spectrophotometry and methylene blue staining methods were used. Excel and SPSS 11 softwares were used to determine amounts and to infer the difference between control and treatment samples. Results: Results obtained from spectrophotometry and analyses of methylene blue staining showed that the Matricaria chamomilla extract at the concentration of 3000 μg/ml caused a significant decrease in the yeast growth and reduced the cells survival rate up to 48% (p< 0.05). Conclusion: Results of this research confirm that the hydroalcoholic extract of Matricaria chamomilla has antiproliferative effect on Saccharomyces cerevisiae.http://www.herbmedpharmacol.com/PDF/JHP-2-49.pdfMatricaria chamomillaSaccharomyces cerevisiaeAntiproliferative effect |
| spellingShingle | Hosseinpour Maryam Mobini-Dehkordi Mohsen Saffar Behnaz Teimori Hossein Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae Journal of HerbMed Pharmacology Matricaria chamomilla Saccharomyces cerevisiae Antiproliferative effect |
| title | Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae |
| title_full | Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae |
| title_fullStr | Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae |
| title_full_unstemmed | Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae |
| title_short | Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae |
| title_sort | antiproliferative effects of matricaria chamomilla on saccharomyces cerevisiae |
| topic | Matricaria chamomilla Saccharomyces cerevisiae Antiproliferative effect |
| url | http://www.herbmedpharmacol.com/PDF/JHP-2-49.pdf |
| work_keys_str_mv | AT hosseinpourmaryam antiproliferativeeffectsofmatricariachamomillaonsaccharomycescerevisiae AT mobinidehkordimohsen antiproliferativeeffectsofmatricariachamomillaonsaccharomycescerevisiae AT saffarbehnaz antiproliferativeeffectsofmatricariachamomillaonsaccharomycescerevisiae AT teimorihossein antiproliferativeeffectsofmatricariachamomillaonsaccharomycescerevisiae |