Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary
Cancer of unknown primary (CUP) is a heterogeneous tumor type that has been diagnosed as a metastatic tumor by pathological examination, but the primary tumor cannot be identified through comprehensive clinical examination. The incidence of CUP accounts for approximately 1%–2% of all tumors. CUP pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0770 |
| _version_ | 1827395858464768000 |
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| author | QI Peng SUN Yifeng XU Qinghua ZHOU Xiaoyan |
| author_facet | QI Peng SUN Yifeng XU Qinghua ZHOU Xiaoyan |
| author_sort | QI Peng |
| collection | DOAJ |
| description | Cancer of unknown primary (CUP) is a heterogeneous tumor type that has been diagnosed as a metastatic tumor by pathological examination, but the primary tumor cannot be identified through comprehensive clinical examination. The incidence of CUP accounts for approximately 1%–2% of all tumors. CUP progresses rapidly and has a short course. The treatment and prognosis of patients with CUP are closely linked to the primary site. In clinical settings, identifying the primary tumor remains challenging. Scholars have focused on improving the detection rate. Novel technologies, such as gene expression profiling, high-throughput sequencing, epigenetics, and liquid biopsy, have been successively applied to identify the primary tumor of CUP accurately, sensitively and specifically. With the guidance of molecular diagnosis, targeted therapy, immunotherapy, and combination therapy will usher in the era of precision treatment for CUP, which may become a typical example for individualized therapy. |
| first_indexed | 2024-03-08T18:41:58Z |
| format | Article |
| id | doaj.art-7118a623e291478e875da272611ecec5 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-08T18:41:58Z |
| publishDate | 2023-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-7118a623e291478e875da272611ecec52023-12-29T06:02:13ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-12-0150121160116410.3971/j.issn.1000-8578.2023.23.07708578.2023.23.0770Current Status and Progress of Diagnostic Techniques for Cancer of Unknown PrimaryQI Peng0SUN Yifeng1XU Qinghua2ZHOU Xiaoyan3Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaShanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, ChinaCanhelp Genomics Co., Ltd., Hangzhou 311100, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaCancer of unknown primary (CUP) is a heterogeneous tumor type that has been diagnosed as a metastatic tumor by pathological examination, but the primary tumor cannot be identified through comprehensive clinical examination. The incidence of CUP accounts for approximately 1%–2% of all tumors. CUP progresses rapidly and has a short course. The treatment and prognosis of patients with CUP are closely linked to the primary site. In clinical settings, identifying the primary tumor remains challenging. Scholars have focused on improving the detection rate. Novel technologies, such as gene expression profiling, high-throughput sequencing, epigenetics, and liquid biopsy, have been successively applied to identify the primary tumor of CUP accurately, sensitively and specifically. With the guidance of molecular diagnosis, targeted therapy, immunotherapy, and combination therapy will usher in the era of precision treatment for CUP, which may become a typical example for individualized therapy.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0770cancer of unknown primarymolecular diagnosticsgene detectiontargeted therapyimmunotherapy |
| spellingShingle | QI Peng SUN Yifeng XU Qinghua ZHOU Xiaoyan Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary Zhongliu Fangzhi Yanjiu cancer of unknown primary molecular diagnostics gene detection targeted therapy immunotherapy |
| title | Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary |
| title_full | Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary |
| title_fullStr | Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary |
| title_full_unstemmed | Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary |
| title_short | Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary |
| title_sort | current status and progress of diagnostic techniques for cancer of unknown primary |
| topic | cancer of unknown primary molecular diagnostics gene detection targeted therapy immunotherapy |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0770 |
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