The Role of Decorin Proteoglycan in Mitophagy
Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surf...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/3/804 |
| _version_ | 1797488649334423552 |
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| author | Thomas Neill Renato V. Iozzo |
| author_facet | Thomas Neill Renato V. Iozzo |
| author_sort | Thomas Neill |
| collection | DOAJ |
| description | Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor. As a member of the small leucine-rich proteoglycan gene family, decorin has single-handedly pioneered the connection between extracellular matrix signaling and autophagy regulation. Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacting with VEGFR2 or the MET receptor tyrosine kinase, respectively. In this paper, we give a mechanistic perspective of the vital factors underlying the nutrient-independent, SLRP-dependent programs utilized for autophagic and/or mitophagic progression in breast cancer. Future protein therapies based on decorin (or fellow proteoglycan members) will represent a quantum leap forward in transforming autophagic progression into a powerful tool to control intracellular cell catabolism from the outside. |
| first_indexed | 2024-03-10T00:05:18Z |
| format | Article |
| id | doaj.art-7118adb321e649b1a9b20537bc2e836f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:05:18Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7118adb321e649b1a9b20537bc2e836f2023-11-23T16:08:56ZengMDPI AGCancers2072-66942022-02-0114380410.3390/cancers14030804The Role of Decorin Proteoglycan in MitophagyThomas Neill0Renato V. Iozzo1Department of Pathology, Anatomy and Cell Biology and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Pathology, Anatomy and Cell Biology and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USAProteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor. As a member of the small leucine-rich proteoglycan gene family, decorin has single-handedly pioneered the connection between extracellular matrix signaling and autophagy regulation. Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacting with VEGFR2 or the MET receptor tyrosine kinase, respectively. In this paper, we give a mechanistic perspective of the vital factors underlying the nutrient-independent, SLRP-dependent programs utilized for autophagic and/or mitophagic progression in breast cancer. Future protein therapies based on decorin (or fellow proteoglycan members) will represent a quantum leap forward in transforming autophagic progression into a powerful tool to control intracellular cell catabolism from the outside.https://www.mdpi.com/2072-6694/14/3/804small leucine-rich proteoglycansautophagyPeg3VEGFR2METmitostatin |
| spellingShingle | Thomas Neill Renato V. Iozzo The Role of Decorin Proteoglycan in Mitophagy Cancers small leucine-rich proteoglycans autophagy Peg3 VEGFR2 MET mitostatin |
| title | The Role of Decorin Proteoglycan in Mitophagy |
| title_full | The Role of Decorin Proteoglycan in Mitophagy |
| title_fullStr | The Role of Decorin Proteoglycan in Mitophagy |
| title_full_unstemmed | The Role of Decorin Proteoglycan in Mitophagy |
| title_short | The Role of Decorin Proteoglycan in Mitophagy |
| title_sort | role of decorin proteoglycan in mitophagy |
| topic | small leucine-rich proteoglycans autophagy Peg3 VEGFR2 MET mitostatin |
| url | https://www.mdpi.com/2072-6694/14/3/804 |
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