Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea
Sanja Jelic1,  David J Lederer1, Tessa Adams1, Margherita Padeletti1, Paolo C Colombo2, Phillip Factor1, Thierry H Le Jemtel31Division of Pulmonary, Allergy, and Critical Care Medicine, 2Division of Cardiology, Columbia University College of Physicians and Surgeons, New Yor...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-11-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/endothelial-repair-capacity-and-apoptosis-are-inversely-related-in-obs-a3692 |
| _version_ | 1818345562474283008 |
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| author | Sanja Jelic,  David J Lederer Tessa Adams et al. |
| author_facet | Sanja Jelic,  David J Lederer Tessa Adams et al. |
| author_sort | Sanja Jelic,  David J Lederer |
| collection | DOAJ |
| description | Sanja Jelic1,  David J Lederer1, Tessa Adams1, Margherita Padeletti1, Paolo C Colombo2, Phillip Factor1, Thierry H Le Jemtel31Division of Pulmonary, Allergy, and Critical Care Medicine, 2Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY, USA; 3Division of Cardiology, Tulane University School of Medicine, New Orleans, LA, USAPurpose: To investigate the impact of obstructive sleep apnea (OSA) on endothelial repair capacity and apoptosis in the absence of potentially confounding factors including obesity. Patients and methods: Sixteen patients with a body mass index <30 and newly diagnosed OSA and 16 controls were studied. Circulating levels of endothelial progenitor cells, a marker of endothelial repair capacity, and endothelial microparticles, a marker of endothelial apoptosis, were quantified before and after four-week therapy with continuous positive airway pressure (CPAP). Endothelial cell apoptotic rate was also quantified in freshly harvested venous endothelial cells. Vascular reactivity was measured by flow-mediated dilation.Results: Before treatment, endothelial microparticle levels were greater and endothelial progenitor cell levels were lower in patients with OSA than in controls (P < 0.001 for both). Levels of endothelial microparticles and progenitors cells were inversely related (r = -0.67, P < 0.001). Endothelial progenitor cell levels increased after effective treatment (P = 0.036). Conclusions: In the absence of any co-morbid conditions including obesity, OSA alone impairs endothelial repair capacity and promotes endothelial apoptosis. These early endothelial alterations may underlie accelerated atherosclerosis and increased cardiovascular risk in OSA. Keywords: sleep apnea, endothelium, apoptosis, endothelial repair capacity |
| first_indexed | 2024-12-13T17:04:21Z |
| format | Article |
| id | doaj.art-7118ed0ae0d54319b1da8feb797767a7 |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-12-13T17:04:21Z |
| publishDate | 2009-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-7118ed0ae0d54319b1da8feb797767a72022-12-21T23:37:43ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482009-11-012009default909920Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apneaSanja Jelic,  David J LedererTessa Adamset al.Sanja Jelic1,  David J Lederer1, Tessa Adams1, Margherita Padeletti1, Paolo C Colombo2, Phillip Factor1, Thierry H Le Jemtel31Division of Pulmonary, Allergy, and Critical Care Medicine, 2Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY, USA; 3Division of Cardiology, Tulane University School of Medicine, New Orleans, LA, USAPurpose: To investigate the impact of obstructive sleep apnea (OSA) on endothelial repair capacity and apoptosis in the absence of potentially confounding factors including obesity. Patients and methods: Sixteen patients with a body mass index <30 and newly diagnosed OSA and 16 controls were studied. Circulating levels of endothelial progenitor cells, a marker of endothelial repair capacity, and endothelial microparticles, a marker of endothelial apoptosis, were quantified before and after four-week therapy with continuous positive airway pressure (CPAP). Endothelial cell apoptotic rate was also quantified in freshly harvested venous endothelial cells. Vascular reactivity was measured by flow-mediated dilation.Results: Before treatment, endothelial microparticle levels were greater and endothelial progenitor cell levels were lower in patients with OSA than in controls (P < 0.001 for both). Levels of endothelial microparticles and progenitors cells were inversely related (r = -0.67, P < 0.001). Endothelial progenitor cell levels increased after effective treatment (P = 0.036). Conclusions: In the absence of any co-morbid conditions including obesity, OSA alone impairs endothelial repair capacity and promotes endothelial apoptosis. These early endothelial alterations may underlie accelerated atherosclerosis and increased cardiovascular risk in OSA. Keywords: sleep apnea, endothelium, apoptosis, endothelial repair capacityhttp://www.dovepress.com/endothelial-repair-capacity-and-apoptosis-are-inversely-related-in-obs-a3692 |
| spellingShingle | Sanja Jelic,  David J Lederer Tessa Adams et al. Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea Vascular Health and Risk Management |
| title | Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| title_full | Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| title_fullStr | Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| title_full_unstemmed | Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| title_short | Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| title_sort | endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea |
| url | http://www.dovepress.com/endothelial-repair-capacity-and-apoptosis-are-inversely-related-in-obs-a3692 |
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