Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine
Summary: The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium that protects against tissue damage and injury-ind...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900421930032X |
| _version_ | 1818419606677618688 |
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| author | Trevor M. Darby Joshua A. Owens Bejan J. Saeedi Liping Luo Jason D. Matthews Brian S. Robinson Crystal R. Naudin Rheinallt M. Jones |
| author_facet | Trevor M. Darby Joshua A. Owens Bejan J. Saeedi Liping Luo Jason D. Matthews Brian S. Robinson Crystal R. Naudin Rheinallt M. Jones |
| author_sort | Trevor M. Darby |
| collection | DOAJ |
| description | Summary: The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium that protects against tissue damage and injury-induced inflammation in the gut. We first employed the Drosophila animal model to screen for the capacity of candidate beneficial bacteria to protect the fly gut against injury. From this screen, we identified Lactococcus lactis subsp. cremoris as a bacterium that elicited potent cytoprotective activity. Then, in a murine model, we demonstrated that the same strain confers powerful cytoprotective influences against radiological damage, as well as anti-inflammatory activity in a gut colitis model. In summary, we demonstrate the positive salutary effects of a beneficial bacterium, namely, L. lactis subsp. cremoris on intestinal tissue and propose the use of this strain as a therapeutic to promote intestinal health. : Biological Sciences; Microbiology; Cell Biology Subject Areas: Biological Sciences, Microbiology, Cell Biology |
| first_indexed | 2024-12-14T12:41:15Z |
| format | Article |
| id | doaj.art-711b1f38f787445d962489da4175aaad |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-14T12:41:15Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-711b1f38f787445d962489da4175aaad2022-12-21T23:00:54ZengElsevieriScience2589-00422019-02-0112356367Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the IntestineTrevor M. Darby0Joshua A. Owens1Bejan J. Saeedi2Liping Luo3Jason D. Matthews4Brian S. Robinson5Crystal R. Naudin6Rheinallt M. Jones7Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USADepartment of Pathology, Emory University School of Medicine, Atlanta GA 30322, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USADepartment of Pathology, Emory University School of Medicine, Atlanta GA 30322, USADepartment of Pathology, Emory University School of Medicine, Atlanta GA 30322, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USA; Corresponding authorSummary: The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium that protects against tissue damage and injury-induced inflammation in the gut. We first employed the Drosophila animal model to screen for the capacity of candidate beneficial bacteria to protect the fly gut against injury. From this screen, we identified Lactococcus lactis subsp. cremoris as a bacterium that elicited potent cytoprotective activity. Then, in a murine model, we demonstrated that the same strain confers powerful cytoprotective influences against radiological damage, as well as anti-inflammatory activity in a gut colitis model. In summary, we demonstrate the positive salutary effects of a beneficial bacterium, namely, L. lactis subsp. cremoris on intestinal tissue and propose the use of this strain as a therapeutic to promote intestinal health. : Biological Sciences; Microbiology; Cell Biology Subject Areas: Biological Sciences, Microbiology, Cell Biologyhttp://www.sciencedirect.com/science/article/pii/S258900421930032X |
| spellingShingle | Trevor M. Darby Joshua A. Owens Bejan J. Saeedi Liping Luo Jason D. Matthews Brian S. Robinson Crystal R. Naudin Rheinallt M. Jones Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine iScience |
| title | Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine |
| title_full | Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine |
| title_fullStr | Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine |
| title_full_unstemmed | Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine |
| title_short | Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine |
| title_sort | lactococcus lactis subsp cremoris is an efficacious beneficial bacterium that limits tissue injury in the intestine |
| url | http://www.sciencedirect.com/science/article/pii/S258900421930032X |
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