Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep
The most common sheep breeds of Egypt are Ossimi, Rahmani, and Barki breeds. The latter one is well adapted to the challenging desert environment, characterized by food shortage and a high temperature fluctuation. Growth performance of Barki sheep has an important economic value in terms of minimizi...
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MDPI AG
2020-01-01
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| Online Access: | https://www.mdpi.com/2076-2615/10/2/197 |
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| author | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Muráni Mosaad Mourad Mohamed Abdel-Salam Rashed Ismail Mohamed Klaus Wimmers |
| author_facet | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Muráni Mosaad Mourad Mohamed Abdel-Salam Rashed Ismail Mohamed Klaus Wimmers |
| author_sort | Ibrahim Abousoliman |
| collection | DOAJ |
| description | The most common sheep breeds of Egypt are Ossimi, Rahmani, and Barki breeds. The latter one is well adapted to the challenging desert environment, characterized by food shortage and a high temperature fluctuation. Growth performance of Barki sheep has an important economic value in terms of minimizing the shortage of mutton meat in Egypt. Further, milk production is of great importance for feeding newborn lambs. Eight candidate genes, recently associated with production traits in different breeds, were used to study the effect of genotype on lamb growth and ewe milk traits. The examined genes were <i>LEP, IGF1, DGAT1, STAT5A, PRL, CSN1S2, GHR,</i> and <i>GHRHR</i>, of which one representative single nucleotide polymorphism (SNP) located in the coding region was selected for genotyping. Data from 251 Barki sheep were used in this study. Association analysis between SNPs and lamb growth traits identified rs420693815 of the <i>LEP</i> gene to be significantly associated with weaning weight and average daily gain. In ewes, significant effects on milk yield and composition have been estimated for <i>LEP</i> (rs420693815), <i>STAT5A</i> (rs161082816), <i>PRL</i> (rs422713690), and <i>GHRHR</i> (rs414991449). The results indicated that these genes might be considered as interesting candidates for further investigations to improve growth and milk performance in Barki sheep. |
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| spelling | doaj.art-711d1c8b63da4480818ea44429723bc32022-12-22T00:59:17ZengMDPI AGAnimals2076-26152020-01-0110219710.3390/ani10020197ani10020197Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki SheepIbrahim Abousoliman0Henry Reyer1Michael Oster2Eduard Muráni3Mosaad Mourad4Mohamed Abdel-Salam Rashed5Ismail Mohamed6Klaus Wimmers7Institute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyFaculty of Agriculture, Ain Shams University, Hadayek Shobra, 11241 Cairo, EgyptFaculty of Agriculture, Ain Shams University, Hadayek Shobra, 11241 Cairo, EgyptDepartment of Animal and Poultry Breeding, Desert Research Center, 1 Mathaf El-Matareya st, 11753 El-Matareya, Cairo, EgyptInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyThe most common sheep breeds of Egypt are Ossimi, Rahmani, and Barki breeds. The latter one is well adapted to the challenging desert environment, characterized by food shortage and a high temperature fluctuation. Growth performance of Barki sheep has an important economic value in terms of minimizing the shortage of mutton meat in Egypt. Further, milk production is of great importance for feeding newborn lambs. Eight candidate genes, recently associated with production traits in different breeds, were used to study the effect of genotype on lamb growth and ewe milk traits. The examined genes were <i>LEP, IGF1, DGAT1, STAT5A, PRL, CSN1S2, GHR,</i> and <i>GHRHR</i>, of which one representative single nucleotide polymorphism (SNP) located in the coding region was selected for genotyping. Data from 251 Barki sheep were used in this study. Association analysis between SNPs and lamb growth traits identified rs420693815 of the <i>LEP</i> gene to be significantly associated with weaning weight and average daily gain. In ewes, significant effects on milk yield and composition have been estimated for <i>LEP</i> (rs420693815), <i>STAT5A</i> (rs161082816), <i>PRL</i> (rs422713690), and <i>GHRHR</i> (rs414991449). The results indicated that these genes might be considered as interesting candidates for further investigations to improve growth and milk performance in Barki sheep.https://www.mdpi.com/2076-2615/10/2/197barki sheepgrowth traitsmilk performancesingle nucleotide polymorphismassociation analysis |
| spellingShingle | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Muráni Mosaad Mourad Mohamed Abdel-Salam Rashed Ismail Mohamed Klaus Wimmers Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep Animals barki sheep growth traits milk performance single nucleotide polymorphism association analysis |
| title | Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep |
| title_full | Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep |
| title_fullStr | Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep |
| title_full_unstemmed | Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep |
| title_short | Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep |
| title_sort | analysis of candidate genes for growth and milk performance traits in the egyptian barki sheep |
| topic | barki sheep growth traits milk performance single nucleotide polymorphism association analysis |
| url | https://www.mdpi.com/2076-2615/10/2/197 |
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