Neurovisceral phenotypes in the expression of psychiatric symptoms
This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Res...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00004/full |
| _version_ | 1818318084714266624 |
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| author | Jessica Anne Eccles Jessica Anne Eccles Andrew Paul Owens Andrew Paul Owens Christopher J Mathias Christopher J Mathias Satoshi eUmeda Hugo D Critchley Hugo D Critchley Hugo D Critchley |
| author_facet | Jessica Anne Eccles Jessica Anne Eccles Andrew Paul Owens Andrew Paul Owens Christopher J Mathias Christopher J Mathias Satoshi eUmeda Hugo D Critchley Hugo D Critchley Hugo D Critchley |
| author_sort | Jessica Anne Eccles |
| collection | DOAJ |
| description | This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Research is revealing how brain-body mechanisms underlie individual differences in psychophysiological reactivity that can be important s for predicting, stratifying and treating individuals with anxiety disorders and related conditions. One common constitutional difference is Joint Hypermobility, in which there is an increased range of joint movement as a result of a variant of collagen. Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-sensitive medical conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. Structural differences in ‘emotional’ brain regions are reported in hypermobile individuals, and many people with joint hypermobility manifest autonomic abnormalities, typically Postural Tachycardia Syndrome. Enhanced heart rate reactivity is characteristic of Postural Tachycardia Syndrome, and there is a phenomenological overlap with anxiety disorders, which may be partially accounted for by exaggerated neural reactivity within ventromedial prefrontal cortex. People who experience Vasovagal Syncope, a heritable tendency to fainting induced by emotional challenges (and needle/ blood phobia), are also more vulnerable to anxiety disorders. Neuroimaging implicates brainstem differences in vulnerability to faints, yet the structural integrity of the caudate nucleus appears important for the control of fainting frequency in relation to parasympathetic tone and anxiety. Together there is clinical and neuroanatomical evidence to show that common constitutional differences affecting autonomic responsivity are linked to psychiatric symptoms, notably anxiety |
| first_indexed | 2024-12-13T09:47:36Z |
| format | Article |
| id | doaj.art-711d8da99a1148159ee0ab0d9cc88f70 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T09:47:36Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-711d8da99a1148159ee0ab0d9cc88f702022-12-21T23:52:01ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-02-01910.3389/fnins.2015.00004120041Neurovisceral phenotypes in the expression of psychiatric symptomsJessica Anne Eccles0Jessica Anne Eccles1Andrew Paul Owens2Andrew Paul Owens3Christopher J Mathias4Christopher J Mathias5Satoshi eUmeda6Hugo D Critchley7Hugo D Critchley8Hugo D Critchley9Brighton and Sussex Medical SchoolSussex Partnership NHS Foundation TrustNational Hospital Neurology Neurosurgery, UCL NHS TrustInsitute of Nuerology, University College LondonNational Hospital Neurology Neurosurgery, UCL NHS TrustInsitute of Nuerology, University College LondonDepartment of Psychology, Keio UniversityBrighton and Sussex Medical SchoolSussex Partnership NHS Foundation TrustSackler Centre for Consciousness Science, University of SussexThis review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Research is revealing how brain-body mechanisms underlie individual differences in psychophysiological reactivity that can be important s for predicting, stratifying and treating individuals with anxiety disorders and related conditions. One common constitutional difference is Joint Hypermobility, in which there is an increased range of joint movement as a result of a variant of collagen. Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-sensitive medical conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. Structural differences in ‘emotional’ brain regions are reported in hypermobile individuals, and many people with joint hypermobility manifest autonomic abnormalities, typically Postural Tachycardia Syndrome. Enhanced heart rate reactivity is characteristic of Postural Tachycardia Syndrome, and there is a phenomenological overlap with anxiety disorders, which may be partially accounted for by exaggerated neural reactivity within ventromedial prefrontal cortex. People who experience Vasovagal Syncope, a heritable tendency to fainting induced by emotional challenges (and needle/ blood phobia), are also more vulnerable to anxiety disorders. Neuroimaging implicates brainstem differences in vulnerability to faints, yet the structural integrity of the caudate nucleus appears important for the control of fainting frequency in relation to parasympathetic tone and anxiety. Together there is clinical and neuroanatomical evidence to show that common constitutional differences affecting autonomic responsivity are linked to psychiatric symptoms, notably anxietyhttp://journal.frontiersin.org/Journal/10.3389/fnins.2015.00004/fullAnxietyPsychiatryvasovagal syncopepostural tachycardia syndromejoint hypermobility |
| spellingShingle | Jessica Anne Eccles Jessica Anne Eccles Andrew Paul Owens Andrew Paul Owens Christopher J Mathias Christopher J Mathias Satoshi eUmeda Hugo D Critchley Hugo D Critchley Hugo D Critchley Neurovisceral phenotypes in the expression of psychiatric symptoms Frontiers in Neuroscience Anxiety Psychiatry vasovagal syncope postural tachycardia syndrome joint hypermobility |
| title | Neurovisceral phenotypes in the expression of psychiatric symptoms |
| title_full | Neurovisceral phenotypes in the expression of psychiatric symptoms |
| title_fullStr | Neurovisceral phenotypes in the expression of psychiatric symptoms |
| title_full_unstemmed | Neurovisceral phenotypes in the expression of psychiatric symptoms |
| title_short | Neurovisceral phenotypes in the expression of psychiatric symptoms |
| title_sort | neurovisceral phenotypes in the expression of psychiatric symptoms |
| topic | Anxiety Psychiatry vasovagal syncope postural tachycardia syndrome joint hypermobility |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00004/full |
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