A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats
Folium mori (桑葉 Sāng Yè, leaf of Morus alba L.; FM) is known to possess hypoglycemic effects, and 1-deoxynojirimycin (1-DNJ) has been proposed as an important functional compound in FM. However, the hypoglycemic activity of purified 1-DNJ has been rarely studied. It is also not known how FM and 1-DN...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-07-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016302292 |
| _version_ | 1811306428112044032 |
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| author | Shiang-Suo Huang Yi-Hui Yan Chien-Hui Ko Ke-Ming Chen Shih-Chieh Lee Cheng-Tzu Liu |
| author_facet | Shiang-Suo Huang Yi-Hui Yan Chien-Hui Ko Ke-Ming Chen Shih-Chieh Lee Cheng-Tzu Liu |
| author_sort | Shiang-Suo Huang |
| collection | DOAJ |
| description | Folium mori (桑葉 Sāng Yè, leaf of Morus alba L.; FM) is known to possess hypoglycemic effects, and 1-deoxynojirimycin (1-DNJ) has been proposed as an important functional compound in FM. However, the hypoglycemic activity of purified 1-DNJ has been rarely studied. It is also not known how FM and 1-DNJ affect the development of DM nephropathy. This study compared the antidiabetic effect of a commercial FM product with that of purified 1-DNJ in streptozotocin-induced diabetic rats. Seven days after induction, the diabetic rats were gavaged with FM (1, 3, 10, and 30 mg/kg/day), 1-DNJ (30 mg/kg/day), or vehicle (distilled deionized water; 2 ml/kg/day) for 7 days. All doses of FM ameliorated fasting and post-prandial blood glucose concomitantly with an increase in peripheral and pancreatic levels of insulin and improved homeostasis model assessment (HOMA-IR) in diabetic rats in a dose-dependent manner. Increased thiobarbituric acid reactive substances (TBARS) and nitrate/nitrite levels in the kidney, liver, and muscle of diabetic rats were reversed by all doses of FM. The renal function of the diabetic rats was normalized by all doses of FM, while blood pressure changes were reversed by FM at doses of 3 mg/kg and above. Moreover, most of the above-mentioned parameters were improved by FM at doses of 3 mg/kg and above to a similar extent as that of 1-DNJ. The results showed superior antidiabetic potential of the commercial FM product for glycemic control and protection against the development of diabetic nephropathy. |
| first_indexed | 2024-04-13T08:45:32Z |
| format | Article |
| id | doaj.art-711de7bc803447a1b0392346173ffa56 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-13T08:45:32Z |
| publishDate | 2014-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-711de7bc803447a1b0392346173ffa562022-12-22T02:53:43ZengElsevierJournal of Traditional and Complementary Medicine2225-41102014-07-014316217010.4103/2225-4110.131639A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic RatsShiang-Suo Huang0Yi-Hui Yan1Chien-Hui Ko2Ke-Ming Chen3Shih-Chieh Lee4Cheng-Tzu Liu5Department of Pharmacology and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.Department of Parasitology, Chung Shan Medical University, Taichung, Taiwan.Department of BioIndustry Technology, Da-Yeh University, Dacun, Changhua, Taiwan.School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.Folium mori (桑葉 Sāng Yè, leaf of Morus alba L.; FM) is known to possess hypoglycemic effects, and 1-deoxynojirimycin (1-DNJ) has been proposed as an important functional compound in FM. However, the hypoglycemic activity of purified 1-DNJ has been rarely studied. It is also not known how FM and 1-DNJ affect the development of DM nephropathy. This study compared the antidiabetic effect of a commercial FM product with that of purified 1-DNJ in streptozotocin-induced diabetic rats. Seven days after induction, the diabetic rats were gavaged with FM (1, 3, 10, and 30 mg/kg/day), 1-DNJ (30 mg/kg/day), or vehicle (distilled deionized water; 2 ml/kg/day) for 7 days. All doses of FM ameliorated fasting and post-prandial blood glucose concomitantly with an increase in peripheral and pancreatic levels of insulin and improved homeostasis model assessment (HOMA-IR) in diabetic rats in a dose-dependent manner. Increased thiobarbituric acid reactive substances (TBARS) and nitrate/nitrite levels in the kidney, liver, and muscle of diabetic rats were reversed by all doses of FM. The renal function of the diabetic rats was normalized by all doses of FM, while blood pressure changes were reversed by FM at doses of 3 mg/kg and above. Moreover, most of the above-mentioned parameters were improved by FM at doses of 3 mg/kg and above to a similar extent as that of 1-DNJ. The results showed superior antidiabetic potential of the commercial FM product for glycemic control and protection against the development of diabetic nephropathy.http://www.sciencedirect.com/science/article/pii/S22254110163022921-DeoxynojirimycinDiabetes mellitusFolium moriNephropathyStreptozotocin |
| spellingShingle | Shiang-Suo Huang Yi-Hui Yan Chien-Hui Ko Ke-Ming Chen Shih-Chieh Lee Cheng-Tzu Liu A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats Journal of Traditional and Complementary Medicine 1-Deoxynojirimycin Diabetes mellitus Folium mori Nephropathy Streptozotocin |
| title | A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats |
| title_full | A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats |
| title_fullStr | A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats |
| title_full_unstemmed | A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats |
| title_short | A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats |
| title_sort | comparison of food grade folium mori extract and 1 deoxynojirimycin for glycemic control and renal function in streptozotocin induced diabetic rats |
| topic | 1-Deoxynojirimycin Diabetes mellitus Folium mori Nephropathy Streptozotocin |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016302292 |
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