Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii
Colonization of the pre-transplant lung by multidrug-resistant bacteria affects short- and long-term outcomes of lung transplantation. However, there are no case reports on the colonization of a pre-transplant lung by drug-resistant Acinetobacter baumannii. We report a case of extensively drug resis...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Critical Care Medicine
2015-05-01
|
| Series: | Korean Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | http://www.kjccm.org/upload/pdf/kjccm-2015-30-2-103.pdf |
| _version_ | 1818126752942129152 |
|---|---|
| author | Hwa Young Lee Hea Yon Lee Sae Bom Shin Kab Soo Shin Bong Woo Lee Hwan Wook Kim Seok Lee Seok Chan Kim |
| author_facet | Hwa Young Lee Hea Yon Lee Sae Bom Shin Kab Soo Shin Bong Woo Lee Hwan Wook Kim Seok Lee Seok Chan Kim |
| author_sort | Hwa Young Lee |
| collection | DOAJ |
| description | Colonization of the pre-transplant lung by multidrug-resistant bacteria affects short- and long-term outcomes of lung transplantation. However, there are no case reports on the colonization of a pre-transplant lung by drug-resistant Acinetobacter baumannii. We report a case of extensively drug resistant (XDR) A. baumannii colonization in the tracheobronchial tree that caused severe infectious complications after bilateral lung transplantation. A 23-year-old man diagnosed with bronchiolitis obliterans syndrome (BOS) 4 years earlier with a history of allogenic bone marrow transplantation for acute lymphoblastic leukemia was admitted to the hospital with dyspnea. Due to progressive hypercapnic respiratory failure, long-term mechanical ventilation was started after a tracheostomy was performed, and the patient underwent a bilateral lung transplantation to treat end-stage BOS. After the transplantation, the colonization of XDR A. baumannii caused severe bacterial pneumonia in the early postoperative period. Combined treatment with colistin and meropenem led to recovery from the pneumonia but caused drug-induced renal failure. Because many centers are willing to transplant candidates who are on mechanical ventilation or extracorporeal life support, the incidence of XDR A.
baumannii colonization of pretransplant lungs is expected to increase. Further studies are needed to examine pre-transplant management strategies in patients colonized with XDR A. baumannii. |
| first_indexed | 2024-12-11T07:06:28Z |
| format | Article |
| id | doaj.art-711dfe632bbb4f16b60d1d4e65df05ca |
| institution | Directory Open Access Journal |
| issn | 2383-4870 |
| language | English |
| last_indexed | 2024-12-11T07:06:28Z |
| publishDate | 2015-05-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Korean Journal of Critical Care Medicine |
| spelling | doaj.art-711dfe632bbb4f16b60d1d4e65df05ca2022-12-22T01:16:29ZengKorean Society of Critical Care MedicineKorean Journal of Critical Care Medicine2383-48702015-05-0130210310810.4266/kjccm.2015.30.2.10378Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumanniiHwa Young LeeHea Yon LeeSae Bom ShinKab Soo ShinBong Woo LeeHwan Wook KimSeok LeeSeok Chan KimColonization of the pre-transplant lung by multidrug-resistant bacteria affects short- and long-term outcomes of lung transplantation. However, there are no case reports on the colonization of a pre-transplant lung by drug-resistant Acinetobacter baumannii. We report a case of extensively drug resistant (XDR) A. baumannii colonization in the tracheobronchial tree that caused severe infectious complications after bilateral lung transplantation. A 23-year-old man diagnosed with bronchiolitis obliterans syndrome (BOS) 4 years earlier with a history of allogenic bone marrow transplantation for acute lymphoblastic leukemia was admitted to the hospital with dyspnea. Due to progressive hypercapnic respiratory failure, long-term mechanical ventilation was started after a tracheostomy was performed, and the patient underwent a bilateral lung transplantation to treat end-stage BOS. After the transplantation, the colonization of XDR A. baumannii caused severe bacterial pneumonia in the early postoperative period. Combined treatment with colistin and meropenem led to recovery from the pneumonia but caused drug-induced renal failure. Because many centers are willing to transplant candidates who are on mechanical ventilation or extracorporeal life support, the incidence of XDR A. baumannii colonization of pretransplant lungs is expected to increase. Further studies are needed to examine pre-transplant management strategies in patients colonized with XDR A. baumannii.http://www.kjccm.org/upload/pdf/kjccm-2015-30-2-103.pdfAcinetobacter baumannii drug resistance lung transplantation |
| spellingShingle | Hwa Young Lee Hea Yon Lee Sae Bom Shin Kab Soo Shin Bong Woo Lee Hwan Wook Kim Seok Lee Seok Chan Kim Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii Korean Journal of Critical Care Medicine Acinetobacter baumannii drug resistance lung transplantation |
| title | Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii |
| title_full | Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii |
| title_fullStr | Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii |
| title_full_unstemmed | Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii |
| title_short | Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii |
| title_sort | lung transplantation in a patient with pre transplant colonization of extensively drug resistant acinetobacter baumannii |
| topic | Acinetobacter baumannii drug resistance lung transplantation |
| url | http://www.kjccm.org/upload/pdf/kjccm-2015-30-2-103.pdf |
| work_keys_str_mv | AT hwayounglee lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT heayonlee lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT saebomshin lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT kabsooshin lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT bongwoolee lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT hwanwookkim lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT seoklee lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii AT seokchankim lungtransplantationinapatientwithpretransplantcolonizationofextensivelydrugresistantacinetobacterbaumannii |