Patient preferences for atopic dermatitis treatments: a discrete choice experiment
Background Patients with moderate-to-severe atopic dermatitis (AD) experience skin lesions and intense itch that substantially affect quality of life. Patients have choices among systemic AD treatments that offer varied benefit–risk profiles. Objective Measure patients’ willingness to trade off the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2023.2222201 |
| _version_ | 1797683474623102976 |
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| author | Shawn G. Kwatra Peter Lio Stephan Weidinger Brian Calimlim Barry Ladizinski Namita Vigna Willings Botha Carol Mansfield |
| author_facet | Shawn G. Kwatra Peter Lio Stephan Weidinger Brian Calimlim Barry Ladizinski Namita Vigna Willings Botha Carol Mansfield |
| author_sort | Shawn G. Kwatra |
| collection | DOAJ |
| description | Background Patients with moderate-to-severe atopic dermatitis (AD) experience skin lesions and intense itch that substantially affect quality of life. Patients have choices among systemic AD treatments that offer varied benefit–risk profiles. Objective Measure patients’ willingness to trade off the risks and benefits of systemic treatments among individuals with a physician-confirmed diagnosis of moderate-to-severe AD. Methods Patients participated in a discrete choice experiment online survey with a series of choices between hypothetical AD treatments defined by six attributes reflecting benefits and risks of treatments (itch reduction, time until noticeable itch reduction, chance of clear or almost clear skin, risk of serious infection, risk of developing acne, and need for prescription topical steroids). Data were analyzed with a random parameters logit model to quantify preferences and the relative importance of attributes for treatment alternatives. Results Respondents (n = 200) placed the highest relative importance on itch reduction, speed of itch reduction, and skin clearance, and were generally willing to accept clinically relevant levels of risk of serious infection and acne in exchange for treatment benefits. Conclusions Patients with moderate-to-severe AD were willing to trade clinically relevant treatment risks for greater or more rapid itch reduction and skin clearance offered by systemic therapies. |
| first_indexed | 2024-03-12T00:14:57Z |
| format | Article |
| id | doaj.art-711ebe21f3c44c08851ac4a3fe3391f6 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:14:57Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-711ebe21f3c44c08851ac4a3fe3391f62023-09-15T14:28:53ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532023-12-0134110.1080/09546634.2023.22222012222201Patient preferences for atopic dermatitis treatments: a discrete choice experimentShawn G. Kwatra0Peter Lio1Stephan Weidinger2Brian Calimlim3Barry Ladizinski4Namita Vigna5Willings Botha6Carol Mansfield7Department of Dermatology, Johns Hopkins University School of MedicineDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of MedicineDepartment of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus KielAbbVie Inc.AbbVie Inc.AbbVie Inc.RTI Health SolutionsRTI Health SolutionsBackground Patients with moderate-to-severe atopic dermatitis (AD) experience skin lesions and intense itch that substantially affect quality of life. Patients have choices among systemic AD treatments that offer varied benefit–risk profiles. Objective Measure patients’ willingness to trade off the risks and benefits of systemic treatments among individuals with a physician-confirmed diagnosis of moderate-to-severe AD. Methods Patients participated in a discrete choice experiment online survey with a series of choices between hypothetical AD treatments defined by six attributes reflecting benefits and risks of treatments (itch reduction, time until noticeable itch reduction, chance of clear or almost clear skin, risk of serious infection, risk of developing acne, and need for prescription topical steroids). Data were analyzed with a random parameters logit model to quantify preferences and the relative importance of attributes for treatment alternatives. Results Respondents (n = 200) placed the highest relative importance on itch reduction, speed of itch reduction, and skin clearance, and were generally willing to accept clinically relevant levels of risk of serious infection and acne in exchange for treatment benefits. Conclusions Patients with moderate-to-severe AD were willing to trade clinically relevant treatment risks for greater or more rapid itch reduction and skin clearance offered by systemic therapies.http://dx.doi.org/10.1080/09546634.2023.2222201atopic dermatitisconditional relative importancediscrete choice experimentpatient preference |
| spellingShingle | Shawn G. Kwatra Peter Lio Stephan Weidinger Brian Calimlim Barry Ladizinski Namita Vigna Willings Botha Carol Mansfield Patient preferences for atopic dermatitis treatments: a discrete choice experiment Journal of Dermatological Treatment atopic dermatitis conditional relative importance discrete choice experiment patient preference |
| title | Patient preferences for atopic dermatitis treatments: a discrete choice experiment |
| title_full | Patient preferences for atopic dermatitis treatments: a discrete choice experiment |
| title_fullStr | Patient preferences for atopic dermatitis treatments: a discrete choice experiment |
| title_full_unstemmed | Patient preferences for atopic dermatitis treatments: a discrete choice experiment |
| title_short | Patient preferences for atopic dermatitis treatments: a discrete choice experiment |
| title_sort | patient preferences for atopic dermatitis treatments a discrete choice experiment |
| topic | atopic dermatitis conditional relative importance discrete choice experiment patient preference |
| url | http://dx.doi.org/10.1080/09546634.2023.2222201 |
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